Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
Background: Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme’s active site. Analogous mutations can be foun...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/759 |
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| Institution: | Mahidol University |
| Language: | English |