HLA Class-II‒Restricted CD8⁺ T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients

• Main Authors: Qing Zhao, Mubarak Almutairi, Arun Tailor, Adam Lister, Nicolas Harper, James Line, Xiaoli Meng, Jirawat Pratoomwun, Kanoot Jaruthamsophon, Chonlaphat Sukasem, Yonghu Sun, Lele Sun, Monday O. Ogese, David J. MacEwan, Munir Pirmohamed, Jianjun Liu, David A. Ostrov, Hong Liu, Furen Zhang, Dean J. Naisbitt
• Other Authors: Ramathibodi Hospital
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76019
• Institution: Mahidol University

HLA-B∗13:01 is associated with dapsone (DDS)-induced hypersensitivity, and it has been shown that CD4+ and CD8+ T cells are activated by DDS and its nitroso metabolite (nitroso dapsone [DDS-NO]). However, there is a need to define the importance of the HLA association in the disease pathogenesis. Th...