Resolving discordant CYP2D6 genotyping results in Thai subjects: Platform limitations and novel haplotypes

• Main Authors: Yaowaluck Hongkaew, Wendy Y. Wang, Roger Gaedigk, Chonlaphat Sukasem, Andrea Gaedigk
• Other Authors: Bumrungrad International Hospital
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76154
• Institution: Mahidol University

Aim: Several CYP2D6 Luminex xTAG genotype calls were identified as inconsistent or suspicious among Thai subjects and further characterized to identify the root causes. Material & methods: Forty-eight subjects were followed-up with long-range-PCR, quantitative copy number assays and/or Sanger se...