Persistence of neutralizing antibody and its protective efficacy induced by a live attenuated tetravalent dengue vaccine, KD-382, in cynomolgus monkeys

• Main Authors: Masaya Yoshimura, Yasuhiko Shinmura, Tatsuya Shishido, Shota Takagi, Kazuhisa Kameyama, Kengo Sonoda, Sutee Yoksan, Kazuhiko Kimachi
• Other Authors: KM Biologics Co., Ltd.
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Veterinary
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76176
• Institution: Mahidol University

An effective dengue vaccine should induce a long-lasting immune response against all four serotypes simultaneously with a minimum number of immunizations. Our live attenuated tetravalent dengue vaccine candidate, KD-382, was developed using a classical host range mutation strategy (no addition of ar...