The sodium leak channel NALCN regulates cell excitability of pituitary endocrine cells

• Main Authors: Hathaichanok Impheng, Céline Lemmers, Malik Bouasse, Christian Legros, Narawut Pakaprot, Nathalie C. Guérineau, Philippe Lory, Arnaud Monteil
• Other Authors: Siriraj Hospital
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76194
• Institution: Mahidol University

Anterior pituitary endocrine cells that release hormones such as growth hormone and prolactin are excitable and fire action potentials. In these cells, several studies previously showed that extracellular sodium (Na+) removal resulted in a negative shift of the resting membrane potential (RMP) and a...