Targeting akt/mtor and bcl‐2 for autophagic and apoptosis cell death in lung cancer: Novel activity of a polyphenol compound

• Main Authors: Sucharat Tungsukruthai, Onrapak Reamtong, Sittiruk Roytrakul, Suchada Sukrong, Chanida Vinayanwattikun, Pithi Chanvorachote
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76230
• Institution: Mahidol University

Autophagic cell death (ACD) is an alternative death mechanism in resistant malignant cancer cells. In this study, we demonstrated how polyphenol stilbene compound PE5 exhibits po-tent ACD‐promoting activity in lung cancer cells that may offer an opportunity for novel cancer treatment. Cell death cau...