Targeting UCHL1 Induces Cell Cycle Arrest in High-Risk Multiple Myeloma with t(4;14)

• Main Authors: Parin Kamseng, Teerapong Siriboonpiputtana, Teeraya Puavilai, Suporn Chuncharunee, Karan Paisooksantivatana, Takol Chareonsirisuthigul, Mutita Junking, Wannasiri Chiraphapphaiboon, Pa Thai Yenchitsomanus, Budsaba Rerkamnuaychoke
• Other Authors: Siriraj Hospital
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76240
• Institution: Mahidol University

Multiple myeloma (MM) patients considered to be at high cytogenetic risk commonly fail to respond to standard treatment. A thorough understanding of the molecular mechanism of MM development is, therefore, needed. We endeavored to explore the transcriptional signature among different subgroups of ne...