Chemical-genetic interactions of Bacopa monnieri constituents in cells deficient for the DNA repair endonuclease RAD1 appear linked to vacuolar disruption

• Main Authors: Chananya Huangteerakul, Hsu Mon Aung, Thitipa Thosapornvichai, Marisa Duangkaew, Amornrat Naranuntarat Jensen, Suchada Sukrong, Kornkanok Ingkaninan, Laran T. Jensen
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76259
• Institution: Mahidol University

Colorectal cancer is a common cancer worldwide and reduced expression of the DNA repair endonuclease XPF (xeroderma pigmentosum complementation group F) is associated with colorectal cancer. Bacopa monnieri extracts were previously found to exhibit chemical-genetic synthetic lethal effects in a Sacc...