Dexamethasone induces pancreatic β-cell apoptosis through upregulation of trail death receptor

• Main Authors: Kanchana Suksri, Namoiy Semprasert, Mutita Junking, Suchanoot Kutpruek, Thawornchai Limjindaporn, Pa Thai Yenchitsomanus, Suwattanee Kooptiwut
• Other Authors: Siriraj Hospital
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76346
• Institution: Mahidol University

Long-term medication with dexamethasone – a synthetic glucocorticoid (GC) drug – results in hyperglycemia, or steroid-induced diabetes. Although recent studies revealed that dexamethasone directly induces pancreatic β-cell apoptosis, its molecular mechanisms remain unclear. In our initial analysis o...