Melatonin Attenuates High Glucose-Induced Changes in Beta Amyloid Precursor Protein Processing in Human Neuroblastoma Cells

• Main Authors: Chutikorn Nopparat, Worawut Chaopae, Parichart Boontem, Pattarawut Sopha, Prapimpun Wongchitrat, Piyarat Govitrapong
• Other Authors: Chulabhorn Royal Academy
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Neuroscience
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76401
• Institution: Mahidol University

Diabetes mellitus (DM), one of metabolic diseases, has been suggested as a risk factor for Alzheimer’s disease (AD). However, how the metabolic pathway activates amyloid precursor protein (APP) processing enzymes then contributes to the increase of amyloid-beta (Aβ) production, is not clearly unders...