Real-time investigation of the roles of ATP hydrolysis by UvrA and UvrB during DNA damage recognition in nucleotide excision repair

• Main Authors: Thanyalak Kraithong, Jeerus Sucharitakul, Chittanon Buranachai, David Jeruzalmi, Pimchai Chaiyen, Danaya Pakotiprapha
• Other Authors: Vidyasirimedhi Institute of Science and Technology
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76424
• Institution: Mahidol University

Nucleotide excision repair (NER) stands out among other DNA repair systems for its ability to process a diverse set of unrelated DNA lesions. In bacteria, NER damage detection is orchestrated by the UvrA and UvrB proteins, which form the UvrA2-UvrB2 (UvrAB) damage sensing complex. The highly versati...