p53-p72-Δ225-331-V31I identified in a cholangiocarcinoma cell line promotes migration and invasiveness via the downregulation of claudin-1 expression and the activation of Cdc42
TP53 is the most common gene mutated in human cancers, including in cholangiocarcinoma (CCA). The gain-of-function properties of p53 variants are often involved in cancer progression. The present study demon- strated that a truncated del p53 variant, del p53M213, exhibited gain-of-function propertie...
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| Main Authors: | , |
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| Format: | Article |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/76425 |
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| Institution: | Mahidol University |