Associations of serum kisspeptin levels with metabolic and reproductive parameters in men
Central kisspeptin action is well known in reproductive regulation; however, its peripheral action is not well understood. This study aimed to 1) compare serum or cerebrospinal fluid (CSF) kisspeptin levels between different body mass index (BMI) groups 2) compare the levels of kisspeptin between se...
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th-mahidol.764282022-08-04T18:16:40Z Associations of serum kisspeptin levels with metabolic and reproductive parameters in men Chantacha Sitticharoon Pornthira Mutirangura Thitima Chinachoti Arissara Iamaroon Namtip Triyasunant Malika Churintaraphan Issarawan Keadkraichaiwat Pailin Maikaew Rungnapa Sririwichitchai Faculty of Medicine Siriraj Hospital, Mahidol University Biochemistry, Genetics and Molecular Biology Neuroscience Central kisspeptin action is well known in reproductive regulation; however, its peripheral action is not well understood. This study aimed to 1) compare serum or cerebrospinal fluid (CSF) kisspeptin levels between different body mass index (BMI) groups 2) compare the levels of kisspeptin between serum and CSF, and 3) determine correlations between serum or CSF kisspeptin levels with clinical, metabolic, and reproductive parameters. There were 40 male subjects undergoing operations with lumbar puncture anesthesia. Subgroup analysis was performed to compare between the normal (n = 12), overweight (n = 10), and obese groups (n = 17). One lean subject was recruited for correlation analysis. Serum kisspeptin levels were significantly higher in the obese group when compared to the normal weight and overweight groups even after adjusting for age or diastolic blood pressure (DBP) (p < 0.05 all). Serum leptin levels were significantly higher in the obese group when compared to the normal weight and overweight groups (p < 0.05 all). CSF kisspeptin levels were below the minimum detectable concentration for the assay (<0.06 ng/mL). Serum kisspeptin was positively correlated with body weight, BMI, plasma insulin, the homeostatic model assessment for insulin resistance (HOMA-IR), and serum leptin but was negatively correlated with plasma LH (p < 0.05 all). In conclusion, serum kisspeptin was related to obesity, leptin, insulin, and insulin resistance, while CSF kisspeptin was below the limits of detection. Thus, peripheral kisspeptin might have a role in metabolic regulation. 2022-08-04T08:15:53Z 2022-08-04T08:15:53Z 2021-01-01 Article Peptides. Vol.135, (2021) 10.1016/j.peptides.2020.170433 18735169 01969781 2-s2.0-85095787906 https://repository.li.mahidol.ac.th/handle/123456789/76428 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85095787906&origin=inward |
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Biochemistry, Genetics and Molecular Biology Neuroscience Chantacha Sitticharoon Pornthira Mutirangura Thitima Chinachoti Arissara Iamaroon Namtip Triyasunant Malika Churintaraphan Issarawan Keadkraichaiwat Pailin Maikaew Rungnapa Sririwichitchai Associations of serum kisspeptin levels with metabolic and reproductive parameters in men |
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Central kisspeptin action is well known in reproductive regulation; however, its peripheral action is not well understood. This study aimed to 1) compare serum or cerebrospinal fluid (CSF) kisspeptin levels between different body mass index (BMI) groups 2) compare the levels of kisspeptin between serum and CSF, and 3) determine correlations between serum or CSF kisspeptin levels with clinical, metabolic, and reproductive parameters. There were 40 male subjects undergoing operations with lumbar puncture anesthesia. Subgroup analysis was performed to compare between the normal (n = 12), overweight (n = 10), and obese groups (n = 17). One lean subject was recruited for correlation analysis. Serum kisspeptin levels were significantly higher in the obese group when compared to the normal weight and overweight groups even after adjusting for age or diastolic blood pressure (DBP) (p < 0.05 all). Serum leptin levels were significantly higher in the obese group when compared to the normal weight and overweight groups (p < 0.05 all). CSF kisspeptin levels were below the minimum detectable concentration for the assay (<0.06 ng/mL). Serum kisspeptin was positively correlated with body weight, BMI, plasma insulin, the homeostatic model assessment for insulin resistance (HOMA-IR), and serum leptin but was negatively correlated with plasma LH (p < 0.05 all). In conclusion, serum kisspeptin was related to obesity, leptin, insulin, and insulin resistance, while CSF kisspeptin was below the limits of detection. Thus, peripheral kisspeptin might have a role in metabolic regulation. |
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Faculty of Medicine Siriraj Hospital, Mahidol University |
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Faculty of Medicine Siriraj Hospital, Mahidol University Chantacha Sitticharoon Pornthira Mutirangura Thitima Chinachoti Arissara Iamaroon Namtip Triyasunant Malika Churintaraphan Issarawan Keadkraichaiwat Pailin Maikaew Rungnapa Sririwichitchai |
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Article |
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Chantacha Sitticharoon Pornthira Mutirangura Thitima Chinachoti Arissara Iamaroon Namtip Triyasunant Malika Churintaraphan Issarawan Keadkraichaiwat Pailin Maikaew Rungnapa Sririwichitchai |
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Chantacha Sitticharoon |
title |
Associations of serum kisspeptin levels with metabolic and reproductive parameters in men |
title_short |
Associations of serum kisspeptin levels with metabolic and reproductive parameters in men |
title_full |
Associations of serum kisspeptin levels with metabolic and reproductive parameters in men |
title_fullStr |
Associations of serum kisspeptin levels with metabolic and reproductive parameters in men |
title_full_unstemmed |
Associations of serum kisspeptin levels with metabolic and reproductive parameters in men |
title_sort |
associations of serum kisspeptin levels with metabolic and reproductive parameters in men |
publishDate |
2022 |
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https://repository.li.mahidol.ac.th/handle/123456789/76428 |
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1763491235503276032 |