Antihyperlipidemic and antioxidant activities of flavonoid-rich extract of ziziphus lotus (L.) lam. fruits
Ziziphus lotus (L.) Lam. (Z. lotus) is a medicinal plant species that is widely distributed throughout the Mediterranean basin. Moroccans traditionally use it to treat many illnesses thanks to its beneficial medicinal properties. The purpose of this study is to assess the anti-hyperlipidemic and ant...
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th-mahidol.765092022-08-04T18:26:19Z Antihyperlipidemic and antioxidant activities of flavonoid-rich extract of ziziphus lotus (L.) lam. fruits Noureddine Bencheikh Mohamed Bouhrim Ilyass Alami Merrouni Salima Boutahiri Loubna Kharchoufa Mohamed Addi Duangjai Tungmunnithum Christophe Hano Bruno Eto Abdelkhaleq Legssyer Mostafa Elachouri Université de Lille Faculté des Sciences d’Oujda Universite d'Orleans Université Mohammed Premier Oujda Mahidol University Chemical Engineering Computer Science Engineering Materials Science Physics and Astronomy Ziziphus lotus (L.) Lam. (Z. lotus) is a medicinal plant species that is widely distributed throughout the Mediterranean basin. Moroccans traditionally use it to treat many illnesses thanks to its beneficial medicinal properties. The purpose of this study is to assess the anti-hyperlipidemic and antioxidant activities of a flavonoid-rich aqueous extract of Z. lotus fruits (ZLF). The 2-2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the β-carotene bleaching test were used to determine the antioxidant activity of ZLF. The anti-hyperlipidemic effect of the aqueous extract of ZLF (200 and 400 mg/kg) was evaluated in albino mice exposed to the chronic high-fat diet, based on lipid profile, blood sugar, and changes in growth performance. The results showed that the aqueous extract of ZLF rich in flavonoids (2242.89 ± 25 µg QE (quercitin equivalent)/mg), and has a considerable antioxidant power against DPPH radicals (IC50 = 116 ± 0.02 µg/mL) and β-carotene oxidation. The aqueous extract of ZLF also showed a significant anti-hyperlipidemic effect by improving abnormal changes in lipid profile and blood glucose levels in albino mice exposed to a chronic high-fat diet. Our findings suggest that the anti-hyperlipidemic activities of ZLF aqueous extract are correlated with its flavonoid content and antioxidant activity. Therefore, the aqueous extract of ZLF could be an essential therapeutic candidate for hyperlipidemia patients, thanks to its richness in bioactive molecules. 2022-08-04T08:18:22Z 2022-08-04T08:18:22Z 2021-09-01 Article Applied Sciences (Switzerland). Vol.11, No.17 (2021) 10.3390/app11177788 20763417 2-s2.0-85113831755 https://repository.li.mahidol.ac.th/handle/123456789/76509 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85113831755&origin=inward |
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Chemical Engineering Computer Science Engineering Materials Science Physics and Astronomy Noureddine Bencheikh Mohamed Bouhrim Ilyass Alami Merrouni Salima Boutahiri Loubna Kharchoufa Mohamed Addi Duangjai Tungmunnithum Christophe Hano Bruno Eto Abdelkhaleq Legssyer Mostafa Elachouri Antihyperlipidemic and antioxidant activities of flavonoid-rich extract of ziziphus lotus (L.) lam. fruits |
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Ziziphus lotus (L.) Lam. (Z. lotus) is a medicinal plant species that is widely distributed throughout the Mediterranean basin. Moroccans traditionally use it to treat many illnesses thanks to its beneficial medicinal properties. The purpose of this study is to assess the anti-hyperlipidemic and antioxidant activities of a flavonoid-rich aqueous extract of Z. lotus fruits (ZLF). The 2-2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the β-carotene bleaching test were used to determine the antioxidant activity of ZLF. The anti-hyperlipidemic effect of the aqueous extract of ZLF (200 and 400 mg/kg) was evaluated in albino mice exposed to the chronic high-fat diet, based on lipid profile, blood sugar, and changes in growth performance. The results showed that the aqueous extract of ZLF rich in flavonoids (2242.89 ± 25 µg QE (quercitin equivalent)/mg), and has a considerable antioxidant power against DPPH radicals (IC50 = 116 ± 0.02 µg/mL) and β-carotene oxidation. The aqueous extract of ZLF also showed a significant anti-hyperlipidemic effect by improving abnormal changes in lipid profile and blood glucose levels in albino mice exposed to a chronic high-fat diet. Our findings suggest that the anti-hyperlipidemic activities of ZLF aqueous extract are correlated with its flavonoid content and antioxidant activity. Therefore, the aqueous extract of ZLF could be an essential therapeutic candidate for hyperlipidemia patients, thanks to its richness in bioactive molecules. |
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Université de Lille |
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Université de Lille Noureddine Bencheikh Mohamed Bouhrim Ilyass Alami Merrouni Salima Boutahiri Loubna Kharchoufa Mohamed Addi Duangjai Tungmunnithum Christophe Hano Bruno Eto Abdelkhaleq Legssyer Mostafa Elachouri |
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Article |
author |
Noureddine Bencheikh Mohamed Bouhrim Ilyass Alami Merrouni Salima Boutahiri Loubna Kharchoufa Mohamed Addi Duangjai Tungmunnithum Christophe Hano Bruno Eto Abdelkhaleq Legssyer Mostafa Elachouri |
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Noureddine Bencheikh |
title |
Antihyperlipidemic and antioxidant activities of flavonoid-rich extract of ziziphus lotus (L.) lam. fruits |
title_short |
Antihyperlipidemic and antioxidant activities of flavonoid-rich extract of ziziphus lotus (L.) lam. fruits |
title_full |
Antihyperlipidemic and antioxidant activities of flavonoid-rich extract of ziziphus lotus (L.) lam. fruits |
title_fullStr |
Antihyperlipidemic and antioxidant activities of flavonoid-rich extract of ziziphus lotus (L.) lam. fruits |
title_full_unstemmed |
Antihyperlipidemic and antioxidant activities of flavonoid-rich extract of ziziphus lotus (L.) lam. fruits |
title_sort |
antihyperlipidemic and antioxidant activities of flavonoid-rich extract of ziziphus lotus (l.) lam. fruits |
publishDate |
2022 |
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https://repository.li.mahidol.ac.th/handle/123456789/76509 |
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1763493213686988800 |