Manganese-Promoted Regioselective Direct C3-Phosphinoylation of 2-Pyridones
A highly efficient and regioselective manganese-induced radical oxidative direct C−P bond formation between 2-pyridones and secondary phosphine oxides was developed. The C3-selective phosphinoylation was conveniently achieved through a combination of substoichiometric manganese and persulfate oxidan...
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| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/76605 |
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| Institution: | Mahidol University |
| Summary: | A highly efficient and regioselective manganese-induced radical oxidative direct C−P bond formation between 2-pyridones and secondary phosphine oxides was developed. The C3-selective phosphinoylation was conveniently achieved through a combination of substoichiometric manganese and persulfate oxidant under mild conditions. Various 3-phosphinoylated pyridone products can be obtained in moderate to high yields. Preliminary mechanistic studies suggest that the reaction is likely to involve a radical pathway induced by catalytically active Mn3+ species. |
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