Substrate binding mechanism of glycerophosphodiesterase towards organophosphate pesticides

• Main Authors: Nayana Bhat, Bodee Nutho, Alisa Vangnai, Kaito Takahashi, Thanyada Rungrotmongkol
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2022
• Subjects: Chemistry; Materials Science; Physics and Astronomy
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76611
• Institution: Mahidol University

Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a binuclear metallohydrolase, which is capable of catalyzing the hydrolysis of mono-, di-, and tri-ester substrates, including some organophosphate pesticides and degradation products of nerve agents. The GpdQ has attracted recent attent...