Substrate binding mechanism of glycerophosphodiesterase towards organophosphate pesticides

• Main Authors: Nayana Bhat, Bodee Nutho, Alisa Vangnai, Kaito Takahashi, Thanyada Rungrotmongkol
• 其他作者: Chulalongkorn University
• 格式: Article
• 出版: 2022
• 主題: Chemistry; Materials Science; Physics and Astronomy
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/76611

Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a binuclear metallohydrolase, which is capable of catalyzing the hydrolysis of mono-, di-, and tri-ester substrates, including some organophosphate pesticides and degradation products of nerve agents. The GpdQ has attracted recent attent...