Cytotoxic effects and intracellular localization of bin toxin from lysinibacillus sphaericus in human liver cancer cell line

• Main Authors: Simab Kanwal, Shalini Abeysinghe, Monrudee Srisaisup, Panadda Boonserm
• Other Authors: Institute of Molecular Biosciences, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Environmental Science; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/77075
• Institution: Mahidol University

Binary toxin (Bin toxin), BinA and BinB, produced by Lysinibacillus sphaericus has been used as a mosquito-control agent due to its high toxicity against the mosquito larvae. The crystal structures of Bin toxin and non-insecticidal but cytotoxic parasporin-2 toxin share some common structural featur...