SERCAP: is the perfect the enemy of the good?
Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose. This target product profile has dominated anti-malarial drug discovery and development over the past decade. The operational advantage of a single encounter has to be...
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th-mahidol.771652022-08-04T16:03:23Z SERCAP: is the perfect the enemy of the good? Nicholas J. White François H. Nosten Faculty of Tropical Medicine, Mahidol University Nuffield Department of Medicine Immunology and Microbiology Medicine Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose. This target product profile has dominated anti-malarial drug discovery and development over the past decade. The operational advantage of a single encounter has to be balanced against the need for a high dose, reliable absorption, little variability in pharmacokinetic properties, slow elimination (to ensure curative drug exposures in all patients) and a very low rate of vomiting. The demanding aspirational target may have hindered anti-malarial drug development. Aiming for three-day regimens, as in current anti-malarial treatments, would be better. 2022-08-04T08:46:19Z 2022-08-04T08:46:19Z 2021-12-01 Letter Malaria Journal. Vol.20, No.1 (2021) 10.1186/s12936-021-03821-z 14752875 2-s2.0-85109364252 https://repository.li.mahidol.ac.th/handle/123456789/77165 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85109364252&origin=inward |
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Immunology and Microbiology Medicine |
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Immunology and Microbiology Medicine Nicholas J. White François H. Nosten SERCAP: is the perfect the enemy of the good? |
| description |
Single Encounter Radical Cure and Prophylaxis (SERCAP) describes an ideal anti-malarial drug that cures all malaria in a single dose. This target product profile has dominated anti-malarial drug discovery and development over the past decade. The operational advantage of a single encounter has to be balanced against the need for a high dose, reliable absorption, little variability in pharmacokinetic properties, slow elimination (to ensure curative drug exposures in all patients) and a very low rate of vomiting. The demanding aspirational target may have hindered anti-malarial drug development. Aiming for three-day regimens, as in current anti-malarial treatments, would be better. |
| author2 |
Faculty of Tropical Medicine, Mahidol University |
| author_facet |
Faculty of Tropical Medicine, Mahidol University Nicholas J. White François H. Nosten |
| format |
Letter |
| author |
Nicholas J. White François H. Nosten |
| author_sort |
Nicholas J. White |
| title |
SERCAP: is the perfect the enemy of the good? |
| title_short |
SERCAP: is the perfect the enemy of the good? |
| title_full |
SERCAP: is the perfect the enemy of the good? |
| title_fullStr |
SERCAP: is the perfect the enemy of the good? |
| title_full_unstemmed |
SERCAP: is the perfect the enemy of the good? |
| title_sort |
sercap: is the perfect the enemy of the good? |
| publishDate |
2022 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/77165 |
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