Shrimp Parvovirus Circular DNA Fragments Arise From Both Endogenous Viral Elements and the Infecting Virus

• Main Authors: Suparat Taengchaiyaphum, Phasini Buathongkam, Suchitraporn Sukthaworn, Prapatsorn Wongkhaluang, Kallaya Sritunyalucksana, Timothy William Flegel
• Other Authors: National Cancer Institute Thailand
• Format: Article
• Published: 2022
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/77218
• Institution: Mahidol University

Some insects use endogenous reverse transcriptase (RT) to make variable viral copy DNA (vcDNA) fragments from viral RNA in linear (lvcDNA) and circular (cvcDNA) forms. The latter form is easy to extract selectively. The vcDNA produces small interfering RNA (siRNA) variants that inhibit viral replica...