Engineered human monoclonal scfv to receptor binding domain of ebolavirus

• Main Authors: Jaslan Densumite, Siratcha Phanthong, Watee Seesuay, Nitat Sookrung, Urai Chaisri, Wanpen Chaicumpa
• Other Authors: Siriraj Hospital
• Format: Article
• Published: 2022
• Subjects: Immunology and Microbiology; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/77292
• Institution: Mahidol University

(1) Background: Ebolavirus (EBOV) poses as a significant threat for human health by frequently causing epidemics of the highly contagious Ebola virus disease (EVD). EBOV glycoprotein (GP), as a sole surface glycoprotein, needs to be cleaved in endosomes to fully expose a receptor-binding domain (RBD...