Coffee Consumption and Non-alcoholic Fatty Liver Disease: An Umbrella Review and a Systematic Review and Meta-analysis

Background: The effects of coffee consumption on hepatic outcomes are controversial. This study investigated the associations between coffee consumption and the incidence of non-alcoholic fatty liver disease (NAFLD) in the general population and the reduction of liver fibrosis among patients with NA...

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Main Authors: Chayanis Kositamongkol, Sukrit Kanchanasurakit, Chiraphong Auttamalang, Nutkamon Inchai, Thanatchaporn Kabkaew, Sarunporn Kitpark, Nathorn Chaiyakunapruk, Acharaporn Duangjai, Surasak Saokaew, Pochamana Phisalprapa
Other Authors: Siriraj Hospital
Format: Review
Published: 2022
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/77403
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spelling th-mahidol.774032022-08-04T18:19:23Z Coffee Consumption and Non-alcoholic Fatty Liver Disease: An Umbrella Review and a Systematic Review and Meta-analysis Chayanis Kositamongkol Sukrit Kanchanasurakit Chiraphong Auttamalang Nutkamon Inchai Thanatchaporn Kabkaew Sarunporn Kitpark Nathorn Chaiyakunapruk Acharaporn Duangjai Surasak Saokaew Pochamana Phisalprapa Siriraj Hospital University of Phayao Monash University Malaysia University of Utah Health Phrae Hospital Medicine Pharmacology, Toxicology and Pharmaceutics Background: The effects of coffee consumption on hepatic outcomes are controversial. This study investigated the associations between coffee consumption and the incidence of non-alcoholic fatty liver disease (NAFLD) in the general population and the reduction of liver fibrosis among patients with NAFLD. Methods: The study consisted of two parts: an umbrella review and a systematic review and meta-analysis (SRMA). The searches for each part were performed separately using PubMed, EMBASE, Cochrane, Scopus, and CINAHL databases. All articles published up to September 2021 were reviewed. To be eligible, studies for the umbrella review were required to report outcomes that compared the risks of NAFLD in the general population and/or liver fibrosis in patients with NAFLD who did and did not drink coffee. Our SRMA included primary studies reporting the effects of coffee consumption on NAFLD-related outcomes. The outcomes were pooled using a random-effects model and reported in both qualitative and quantitative terms (pooled risk ratio, odds ratio, and weighted mean difference). Results: We identified four published SRMAs during the umbrella review. Most studies showed that individuals in the general population who regularly drank coffee were significantly associated with a lower NAFLD incidence than those who did not. Our SRMA included nine studies on the effects of coffee consumption on NAFLD incidence. Pooled data from 147,875 subjects showed that coffee consumption was not associated with a lower NAFLD incidence in the general population. The between-study heterogeneity was high (I2, 72–85%). Interestingly, among patients with NAFLD (5 studies; n = 3,752), coffee consumption was significantly associated with a reduction in liver fibrosis (odds ratio, 0.67; 95% CI, 0.55 to 0.80; I2, 3%). There were no differences in the coffee consumption of the general population and of those with NAFLD (4 studies; n = 19,482) or by patients with no/mild liver fibrosis and those with significant fibrosis (4 studies; n = 3,331). Conclusions: There are contrasting results on the effects of coffee on NAFLD prevention in the general population. Benefits of coffee consumption on liver fibrosis were seen among patients with NAFLD. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021226607, identifier CRD42021226607 2022-08-04T08:58:03Z 2022-08-04T08:58:03Z 2021-12-13 Review Frontiers in Pharmacology. Vol.12, (2021) 10.3389/fphar.2021.786596 16639812 2-s2.0-85121771281 https://repository.li.mahidol.ac.th/handle/123456789/77403 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85121771281&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Medicine
Pharmacology, Toxicology and Pharmaceutics
Chayanis Kositamongkol
Sukrit Kanchanasurakit
Chiraphong Auttamalang
Nutkamon Inchai
Thanatchaporn Kabkaew
Sarunporn Kitpark
Nathorn Chaiyakunapruk
Acharaporn Duangjai
Surasak Saokaew
Pochamana Phisalprapa
Coffee Consumption and Non-alcoholic Fatty Liver Disease: An Umbrella Review and a Systematic Review and Meta-analysis
description Background: The effects of coffee consumption on hepatic outcomes are controversial. This study investigated the associations between coffee consumption and the incidence of non-alcoholic fatty liver disease (NAFLD) in the general population and the reduction of liver fibrosis among patients with NAFLD. Methods: The study consisted of two parts: an umbrella review and a systematic review and meta-analysis (SRMA). The searches for each part were performed separately using PubMed, EMBASE, Cochrane, Scopus, and CINAHL databases. All articles published up to September 2021 were reviewed. To be eligible, studies for the umbrella review were required to report outcomes that compared the risks of NAFLD in the general population and/or liver fibrosis in patients with NAFLD who did and did not drink coffee. Our SRMA included primary studies reporting the effects of coffee consumption on NAFLD-related outcomes. The outcomes were pooled using a random-effects model and reported in both qualitative and quantitative terms (pooled risk ratio, odds ratio, and weighted mean difference). Results: We identified four published SRMAs during the umbrella review. Most studies showed that individuals in the general population who regularly drank coffee were significantly associated with a lower NAFLD incidence than those who did not. Our SRMA included nine studies on the effects of coffee consumption on NAFLD incidence. Pooled data from 147,875 subjects showed that coffee consumption was not associated with a lower NAFLD incidence in the general population. The between-study heterogeneity was high (I2, 72–85%). Interestingly, among patients with NAFLD (5 studies; n = 3,752), coffee consumption was significantly associated with a reduction in liver fibrosis (odds ratio, 0.67; 95% CI, 0.55 to 0.80; I2, 3%). There were no differences in the coffee consumption of the general population and of those with NAFLD (4 studies; n = 19,482) or by patients with no/mild liver fibrosis and those with significant fibrosis (4 studies; n = 3,331). Conclusions: There are contrasting results on the effects of coffee on NAFLD prevention in the general population. Benefits of coffee consumption on liver fibrosis were seen among patients with NAFLD. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021226607, identifier CRD42021226607
author2 Siriraj Hospital
author_facet Siriraj Hospital
Chayanis Kositamongkol
Sukrit Kanchanasurakit
Chiraphong Auttamalang
Nutkamon Inchai
Thanatchaporn Kabkaew
Sarunporn Kitpark
Nathorn Chaiyakunapruk
Acharaporn Duangjai
Surasak Saokaew
Pochamana Phisalprapa
format Review
author Chayanis Kositamongkol
Sukrit Kanchanasurakit
Chiraphong Auttamalang
Nutkamon Inchai
Thanatchaporn Kabkaew
Sarunporn Kitpark
Nathorn Chaiyakunapruk
Acharaporn Duangjai
Surasak Saokaew
Pochamana Phisalprapa
author_sort Chayanis Kositamongkol
title Coffee Consumption and Non-alcoholic Fatty Liver Disease: An Umbrella Review and a Systematic Review and Meta-analysis
title_short Coffee Consumption and Non-alcoholic Fatty Liver Disease: An Umbrella Review and a Systematic Review and Meta-analysis
title_full Coffee Consumption and Non-alcoholic Fatty Liver Disease: An Umbrella Review and a Systematic Review and Meta-analysis
title_fullStr Coffee Consumption and Non-alcoholic Fatty Liver Disease: An Umbrella Review and a Systematic Review and Meta-analysis
title_full_unstemmed Coffee Consumption and Non-alcoholic Fatty Liver Disease: An Umbrella Review and a Systematic Review and Meta-analysis
title_sort coffee consumption and non-alcoholic fatty liver disease: an umbrella review and a systematic review and meta-analysis
publishDate 2022
url https://repository.li.mahidol.ac.th/handle/123456789/77403
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