Safety, pharmacokinetics, and antiviral activity of RO7049389, a core protein allosteric modulator, in patients with chronic hepatitis B virus infection: a multicentre, randomised, placebo-controlled, phase 1 trial

Safety, pharmacokinetics, and antiviral activity of RO7049389, a core protein allosteric modulator, in patients with chronic hepatitis B virus infection: a multicentre, randomised, placebo-controlled, phase 1 trial

Background: RO7049389, a hepatitis B virus (HBV) core protein allosteric modulator being developed for the treatment of chronic HBV infection, was found to be safe and well tolerated in healthy participants (part 1 of this study). The objective of this proof-of-mechanism study (part 2) was to evalua...

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Main Authors: Man Fung Yuen, Xue Zhou, Edward Gane, Christian Schwabe, Tawesak Tanwandee, Sheng Feng, Yuyan Jin, Miriam Triyatni, Annabelle Lemenuel-Diot, Valerie Cosson, Zenghui Xue, Remi Kazma, Qingyan Bo
Other Authors: Siriraj Hospital
Format: Article
Published: 2022
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/77908
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/77908

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