Whole-genome analysis of drug-resistant Mycobacterium tuberculosis reveals novel mutations associated with fluoroquinolone resistance

• Main Authors: Pratchakan Chaiyachat, Angkana Chaiprasert, Ditthawat Nonghanphithak, Saijai Smithtikarn, Phalin Kamolwat, Petchawan Pungrassami, Wipa Reechaipichitkul, Rick Twee Hee Ong, Yik Ying Teo, Kiatichai Faksri
• Other Authors: Siriraj Hospital
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/77917
• Institution: Mahidol University

Multidrug-resistant and extensively drug-resistant tuberculosis (M/XDR-TB) remains a global public-health challenge. Known mutations in quinolone resistance-determination regions cannot fully explain phenotypic fluoroquinolone (FQ) resistance in Mycobacterium tuberculosis (Mtb). The aim of this stud...