Tpmt*3c as a predictor of 6-mercaptopurine-induced myelotoxicity in thai children with acute lymphoblastic leukemia

• Main Authors: Thawinee Jantararoungtong, Supaporn Wiwattanakul, Rawiporn Tiyasirichokchai, Santirhat Prommas, Rattanaporn Sukprasong, Napatrupron Koomdee, Pimonpan Jinda, Jiratha Rachanakul, Nutthan Nuntharadthanaphong, Samart Pakakasama, Usanarat Anurathapan, Suradej Hongeng, Chonlaphat Sukasem
• Other Authors: Ramathibodi Hospital
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/77989
• Institution: Mahidol University

The response to 6-mercaptopurine (6-MP) can be altered by genetic polymorphisms in genes encoding drug-metabolizing enzymes and drug transporters. The purpose of this study was to investigate the association between genetic polymorphisms of drug-metabolizing enzymes (TPMT 719A > G (*3C), ITPA 94C...