Increased susceptibility to dextran sulfate-induced mucositis of iron-overload β-thalassemia mice, another endogenous cause of septicemia in thalassemia

• Main Authors: Peerapat Visitchanakun, Wimonrat Panpetch, Wilasinee Saisorn, Piraya Chatthanathon, Dhammika Leshan Wannigama, Arthid Thim-Uam, Saovaros Svasti, Suthat Fucharoen, Naraporn Somboonna, Asada Leelahavanichkul
• Other Authors: UWA Medical School
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/78140
• Institution: Mahidol University

Enterocyte damage and gut dysbiosis are caused by iron-overload in thalassemia (Thl), possiblymaking the gut vulnerable to additional injury. Hence, iron-overload in the heterozygous β-globin deficient (Hbbth3/+) mice were tested with 3% dextran sulfate solution (DSS). With 4 months of iron-gavage,...