Development and validation of an in silico decision tool to guide optimization of intravenous artesunate dosing regimens for severe falciparum malaria patients

• Main Authors: Sophie G. Zaloumis, Jason M. Whyte, Joel Tarning, Sanjeev Krishna, James M. McCaw, Pengxing Cao, Michael T. White, Saber Dini, Freya J.I. Fowkes, Richard J. Maude, Peter Kremsner, Arjen Dondorp, Ric N. Price, Nicholas J. White, Julie A. Simpson
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/78166
• Institution: Mahidol University

Most deaths from severe falciparum malaria occur within 24 h of presentation to a hospital. Intravenous (i.v.) artesunate is the first-line treatment for severe falciparum malaria, but its efficacy may be compromised by delayed parasitological responses. In patients with severe malaria, the life-sav...