Exosome-inflammasome crosstalk and their roles in inflammatory responses
Inflammasome is a complex of multiple proteins found in cytoplasm of the cells activated by infectious and/or non-infectious stimuli. This complex involves caspase-1 activation, leading to unconventional secretion of interleukin-1β (IL-1β) and IL-18 and inflammatory cascade. Exosome is the nanoscale...
Saved in:
Main Authors: | , |
---|---|
Other Authors: | |
Format: | Review |
Published: |
2022
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/78355 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.78355 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.783552022-08-04T18:22:51Z Exosome-inflammasome crosstalk and their roles in inflammatory responses Chadanat Noonin Visith Thongboonkerd Siriraj Hospital Medicine Pharmacology, Toxicology and Pharmaceutics Inflammasome is a complex of multiple proteins found in cytoplasm of the cells activated by infectious and/or non-infectious stimuli. This complex involves caspase-1 activation, leading to unconventional secretion of interleukin-1β (IL-1β) and IL-18 and inflammatory cascade. Exosome is the nanoscale membrane-bound extracellular vesicle that plays significant roles in intercellular communications by carrying bioactive molecules, e.g., proteins, RNAs, microRNAs (miRNAs), DNAs, from one cell to the others. In this review, we provide the update information on the crosstalk between exosome and inflammasome and their roles in inflammatory responses. The effects of inflammasome activation on exosomal secretion are summarized. On the other hand, the (dual) effects of exosomes on inhibiting and promoting inflammasome activation are discussed. Finally, perspectives on therapeutic roles of exosomes in human diseases and future direction of the research on exosome-inflammasome crosstalk are provided. 2022-08-04T09:29:03Z 2022-08-04T09:29:03Z 2021-03-04 Review Theranostics. Vol.11, No.9 (2021), 4436-4451 10.7150/THNO.54004 18387640 2-s2.0-85103433883 https://repository.li.mahidol.ac.th/handle/123456789/78355 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85103433883&origin=inward |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Medicine Pharmacology, Toxicology and Pharmaceutics |
spellingShingle |
Medicine Pharmacology, Toxicology and Pharmaceutics Chadanat Noonin Visith Thongboonkerd Exosome-inflammasome crosstalk and their roles in inflammatory responses |
description |
Inflammasome is a complex of multiple proteins found in cytoplasm of the cells activated by infectious and/or non-infectious stimuli. This complex involves caspase-1 activation, leading to unconventional secretion of interleukin-1β (IL-1β) and IL-18 and inflammatory cascade. Exosome is the nanoscale membrane-bound extracellular vesicle that plays significant roles in intercellular communications by carrying bioactive molecules, e.g., proteins, RNAs, microRNAs (miRNAs), DNAs, from one cell to the others. In this review, we provide the update information on the crosstalk between exosome and inflammasome and their roles in inflammatory responses. The effects of inflammasome activation on exosomal secretion are summarized. On the other hand, the (dual) effects of exosomes on inhibiting and promoting inflammasome activation are discussed. Finally, perspectives on therapeutic roles of exosomes in human diseases and future direction of the research on exosome-inflammasome crosstalk are provided. |
author2 |
Siriraj Hospital |
author_facet |
Siriraj Hospital Chadanat Noonin Visith Thongboonkerd |
format |
Review |
author |
Chadanat Noonin Visith Thongboonkerd |
author_sort |
Chadanat Noonin |
title |
Exosome-inflammasome crosstalk and their roles in inflammatory responses |
title_short |
Exosome-inflammasome crosstalk and their roles in inflammatory responses |
title_full |
Exosome-inflammasome crosstalk and their roles in inflammatory responses |
title_fullStr |
Exosome-inflammasome crosstalk and their roles in inflammatory responses |
title_full_unstemmed |
Exosome-inflammasome crosstalk and their roles in inflammatory responses |
title_sort |
exosome-inflammasome crosstalk and their roles in inflammatory responses |
publishDate |
2022 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/78355 |
_version_ |
1763495615874990080 |