Ventilatory effect of midazolam in propofol deep sedation for hepatic tumor patients undergoing percutaneous radiofrequency ablation procedure
Objective: The aim of the study was to compare the ventilatory effect between propofol deep sedation technique with and without midazolam in hepatic tumor patients undergoing radiofrequency ablation procedure. Methods: Three hundred and seventy-four patients who underwent radiofrequency ablation pro...
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th-mahidol.783572022-08-04T16:29:09Z Ventilatory effect of midazolam in propofol deep sedation for hepatic tumor patients undergoing percutaneous radiofrequency ablation procedure Krongthip Sripunjan Pattharaporn Sombood Phongtara Vichitvejpaisal Somchai Amornyotin Faculty of Medicine Siriraj Hospital, Mahidol University Medicine Objective: The aim of the study was to compare the ventilatory effect between propofol deep sedation technique with and without midazolam in hepatic tumor patients undergoing radiofrequency ablation procedure. Methods: Three hundred and seventy-four patients who underwent radiofrequency ablation procedure in a single year were randomly assigned to the deep sedation without midazolam group (A, n = 187) and deep sedation with midazolam group (B, n = 187). Patients in group A received normal saline, and those in group B received 0.02 mg/kg of midazolam intravenously in equivalent volume. All patients were oxygenated with 100% O2 via nasal cannula and sedated with intravenous fentanyl and the titration of intravenous propofol. Ventilatory parameters, including oxygen saturation, end tidal carbon dioxide, and respiratory rate every five minutes, during and after the procedure, as well as the duration of sleep and sedation score in the recovery room, were recorded. Results: There were no significant differences in the patients’ characteristics, duration of procedure, total dose of propofol, ventilatory parameters including oxygen saturation, end tidal carbon dioxide, and respiratory rate, as well as sedation score at 20, 25, 30, 35, and 40 min after the procedure, between the two groups. However, mean sedation score at 5, 10, and 15 min after the procedure, in group B, was significantly lower than in group A. In addition, the duration of sleep after the procedure, in group B, was significantly greater than in group A. No serious ventilatory adverse effects were observed either group. Conclusion: Propofol deep sedation with and without midazolam for hepatic tumor patients who underwent radiofrequency ablation procedure was safe and effective. A low dose of midazolam in propofol deep-sedation technique did not create serious ventilatory effects. 2022-08-04T09:29:09Z 2022-08-04T09:29:09Z 2021-03-03 Article Gastroenterology Insights. Vol.12, No.1 (2021), 89-99 10.3390/GASTROENT12010009 20367422 2-s2.0-85103575630 https://repository.li.mahidol.ac.th/handle/123456789/78357 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85103575630&origin=inward |
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Medicine Krongthip Sripunjan Pattharaporn Sombood Phongtara Vichitvejpaisal Somchai Amornyotin Ventilatory effect of midazolam in propofol deep sedation for hepatic tumor patients undergoing percutaneous radiofrequency ablation procedure |
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Objective: The aim of the study was to compare the ventilatory effect between propofol deep sedation technique with and without midazolam in hepatic tumor patients undergoing radiofrequency ablation procedure. Methods: Three hundred and seventy-four patients who underwent radiofrequency ablation procedure in a single year were randomly assigned to the deep sedation without midazolam group (A, n = 187) and deep sedation with midazolam group (B, n = 187). Patients in group A received normal saline, and those in group B received 0.02 mg/kg of midazolam intravenously in equivalent volume. All patients were oxygenated with 100% O2 via nasal cannula and sedated with intravenous fentanyl and the titration of intravenous propofol. Ventilatory parameters, including oxygen saturation, end tidal carbon dioxide, and respiratory rate every five minutes, during and after the procedure, as well as the duration of sleep and sedation score in the recovery room, were recorded. Results: There were no significant differences in the patients’ characteristics, duration of procedure, total dose of propofol, ventilatory parameters including oxygen saturation, end tidal carbon dioxide, and respiratory rate, as well as sedation score at 20, 25, 30, 35, and 40 min after the procedure, between the two groups. However, mean sedation score at 5, 10, and 15 min after the procedure, in group B, was significantly lower than in group A. In addition, the duration of sleep after the procedure, in group B, was significantly greater than in group A. No serious ventilatory adverse effects were observed either group. Conclusion: Propofol deep sedation with and without midazolam for hepatic tumor patients who underwent radiofrequency ablation procedure was safe and effective. A low dose of midazolam in propofol deep-sedation technique did not create serious ventilatory effects. |
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Faculty of Medicine Siriraj Hospital, Mahidol University |
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Faculty of Medicine Siriraj Hospital, Mahidol University Krongthip Sripunjan Pattharaporn Sombood Phongtara Vichitvejpaisal Somchai Amornyotin |
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Article |
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Krongthip Sripunjan Pattharaporn Sombood Phongtara Vichitvejpaisal Somchai Amornyotin |
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Krongthip Sripunjan |
title |
Ventilatory effect of midazolam in propofol deep sedation for hepatic tumor patients undergoing percutaneous radiofrequency ablation procedure |
title_short |
Ventilatory effect of midazolam in propofol deep sedation for hepatic tumor patients undergoing percutaneous radiofrequency ablation procedure |
title_full |
Ventilatory effect of midazolam in propofol deep sedation for hepatic tumor patients undergoing percutaneous radiofrequency ablation procedure |
title_fullStr |
Ventilatory effect of midazolam in propofol deep sedation for hepatic tumor patients undergoing percutaneous radiofrequency ablation procedure |
title_full_unstemmed |
Ventilatory effect of midazolam in propofol deep sedation for hepatic tumor patients undergoing percutaneous radiofrequency ablation procedure |
title_sort |
ventilatory effect of midazolam in propofol deep sedation for hepatic tumor patients undergoing percutaneous radiofrequency ablation procedure |
publishDate |
2022 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/78357 |
_version_ |
1763492463476998144 |