A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: Is it time to reconsider the current contraindication?

• Main Authors: Podjanee Jittamala, Wuelton Monteiro, Menno R. Smit, Belen Pedrique, Sabine Specht, Carlos J. Chaccour, Céline Dard, Pascal Del Giudice, Virak Khieu, Annabel Maruani, Virgilio E. Failoc-Rojas, Marimar Sáez-De-ocariz, Antoni Soriano-Arandes, Jaime Piquero-Casals, Anne Faisant, Marie Pierre Brenier-Pinchart, David Wimmersberger, Jean T. Coulibaly, Jennifer Keiser, Franck Boralevi, Oliver Sokana, Michael Marks, Daniel Engelman, Lucia Romani, Andrew C. Steer, Lorenz von Seidlein, Nicholas J. White, Eli Harriss, Kasia Stepniewska, Georgina S. Humphreys, Kalynn Kennon, Philippe J. Guerin, Kevin C. Kobylinski
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/78372
• Institution: Mahidol University

Background Oral ivermectin is a safe broad spectrum anthelminthic used for treating several neglected tropical diseases (NTDs). Currently, ivermectin use is contraindicated in children weighing less than 15 kg, restricting access to this drug for the treatment of NTDs. Here we provide an updated sys...