Sleep interventions and glucose metabolism: systematic review and meta-analysis

Objective: Sleep disturbances (insufficient or poor sleep quality) have been linked to abnormal glucose metabolism. This systematic review and meta-analysis aimed to explore the effects of behavioral and pharmacological sleep interventions on glucose metabolism. Methods: Medline and Embase were used...

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Main Authors: Vallari Kothari, Zulma Cardona, Naricha Chirakalwasan, Thunyarat Anothaisintawee, Sirimon Reutrakul
Other Authors: Chulalongkorn University
Format: Review
Published: 2022
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/78487
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Institution: Mahidol University
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spelling th-mahidol.784872022-08-04T18:01:56Z Sleep interventions and glucose metabolism: systematic review and meta-analysis Vallari Kothari Zulma Cardona Naricha Chirakalwasan Thunyarat Anothaisintawee Sirimon Reutrakul Chulalongkorn University University of Illinois at Chicago King Chulalongkorn Memorial Hospital Faculty of Medicine Ramathibodi Hospital, Mahidol University Medicine Objective: Sleep disturbances (insufficient or poor sleep quality) have been linked to abnormal glucose metabolism. This systematic review and meta-analysis aimed to explore the effects of behavioral and pharmacological sleep interventions on glucose metabolism. Methods: Medline and Embase were used for systematic search. Studies reporting behavioral or pharmacological interventions in population with sleep disturbances, with measured outcomes of glucose metabolism and sleep parameters were selected. Results: Twenty two studies were eligible for review (eight were conducted in people with type 2 diabetes). Studies were grouped into three types of intervention: sleep extension (n = 6), sleep education or cognitive behavioral therapy for insomnia (CBT-I, n = 6) and pharmacological interventions (n = 10). CBT-I and sleep education resulted in significantly improved self-reported sleep quality (Pittsburgh Sleep Quality Index, mean difference, MD, −1.31, 95% confidence interval (CI) −1.83, −0.80), non-significant reduction in hemoglobin A1c level (MD -0.35%, 95% CI -0.84, 0.13), and non-significant reduction in fasting glucose levels (MD -4.76 mg/dL, 95% CI -14.19, 4.67). Other studies were not eligible for meta-analysis due to heterogeneity of interventions or outcomes. Sleep extension was able to increase sleep duration by varying degrees in short sleepers, and five of six studies demonstrated relationships between the intervention and measures of insulin resistance. A majority of pharmacological intervention studies showed improved sleep but the effects on glucose metabolism were mixed. Conclusions: Available sleep interventions were effective in improving sleep but the effects on glucose metabolism were inconclusive. Larger randomized studies with consistent outcome measurements are needed to demonstrate this potential causal relationship. 2022-08-04T11:01:56Z 2022-08-04T11:01:56Z 2021-02-01 Review Sleep Medicine. Vol.78, (2021), 24-35 10.1016/j.sleep.2020.11.035 18785506 13899457 2-s2.0-85098234521 https://repository.li.mahidol.ac.th/handle/123456789/78487 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85098234521&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Vallari Kothari
Zulma Cardona
Naricha Chirakalwasan
Thunyarat Anothaisintawee
Sirimon Reutrakul
Sleep interventions and glucose metabolism: systematic review and meta-analysis
description Objective: Sleep disturbances (insufficient or poor sleep quality) have been linked to abnormal glucose metabolism. This systematic review and meta-analysis aimed to explore the effects of behavioral and pharmacological sleep interventions on glucose metabolism. Methods: Medline and Embase were used for systematic search. Studies reporting behavioral or pharmacological interventions in population with sleep disturbances, with measured outcomes of glucose metabolism and sleep parameters were selected. Results: Twenty two studies were eligible for review (eight were conducted in people with type 2 diabetes). Studies were grouped into three types of intervention: sleep extension (n = 6), sleep education or cognitive behavioral therapy for insomnia (CBT-I, n = 6) and pharmacological interventions (n = 10). CBT-I and sleep education resulted in significantly improved self-reported sleep quality (Pittsburgh Sleep Quality Index, mean difference, MD, −1.31, 95% confidence interval (CI) −1.83, −0.80), non-significant reduction in hemoglobin A1c level (MD -0.35%, 95% CI -0.84, 0.13), and non-significant reduction in fasting glucose levels (MD -4.76 mg/dL, 95% CI -14.19, 4.67). Other studies were not eligible for meta-analysis due to heterogeneity of interventions or outcomes. Sleep extension was able to increase sleep duration by varying degrees in short sleepers, and five of six studies demonstrated relationships between the intervention and measures of insulin resistance. A majority of pharmacological intervention studies showed improved sleep but the effects on glucose metabolism were mixed. Conclusions: Available sleep interventions were effective in improving sleep but the effects on glucose metabolism were inconclusive. Larger randomized studies with consistent outcome measurements are needed to demonstrate this potential causal relationship.
author2 Chulalongkorn University
author_facet Chulalongkorn University
Vallari Kothari
Zulma Cardona
Naricha Chirakalwasan
Thunyarat Anothaisintawee
Sirimon Reutrakul
format Review
author Vallari Kothari
Zulma Cardona
Naricha Chirakalwasan
Thunyarat Anothaisintawee
Sirimon Reutrakul
author_sort Vallari Kothari
title Sleep interventions and glucose metabolism: systematic review and meta-analysis
title_short Sleep interventions and glucose metabolism: systematic review and meta-analysis
title_full Sleep interventions and glucose metabolism: systematic review and meta-analysis
title_fullStr Sleep interventions and glucose metabolism: systematic review and meta-analysis
title_full_unstemmed Sleep interventions and glucose metabolism: systematic review and meta-analysis
title_sort sleep interventions and glucose metabolism: systematic review and meta-analysis
publishDate 2022
url https://repository.li.mahidol.ac.th/handle/123456789/78487
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