Optimized Chloroquine Phosphate Dosage Regimens for Early Virological Clearance of Severe Acute Respiratory Syndrome Coronavirus 2 using Monte Carlo Simulation

• Main Authors: Nattapong Tidwong, Baralee Punyawudho, Pannee Leelawattanachai, Suwida Tangtrakultham, Pitchaya Dilokpattanamongkol, Taniya Paiboonvong, Supatat Chumnumwat, Preecha Montakantikul
• Other Authors: Rangsit University
• Format: Article
• Published: 2022
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/78725
• Institution: Mahidol University

Chloroquine (CQ) exhibited promising in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the optimal dosage regimens remain unknown. Our objective was to explore the optimal chloroquine phosphate (CQP) dosage regimens for early achievement of virological clear...