Therapeutic drug monitoring of intravenous busulfan in Thai children undergoing hematopoietic stem cell transplantation: A pilot study

• Main Authors: Thaksin Jansing, Kleebsabai Sanpakit, Trai Tharnpanich, Thanjira Jiranantakan, Vachira Niphandwongkorn, Busba Chindavijak, Thanarat Suansanae
• Other Authors: Siriraj Hospital
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/78738
• Institution: Mahidol University

Busulfan (Bu) is commonly used in myeloablative conditioning regimens for children undergoing hematopoietic stem cell transplantation. The standard target area under the concentration-time curve (AUC) of Bu is approximately 900–1500 µM min. In previous studies using five fixed doses (0.8–1.2 mg/kg)...