Formulation and Pharmaceutical Evaluation of Extemporaneous α-arbutin Creams for the Treatment of Melasma

• Main Authors: Veerawat Teeranachaideekul, Worrawee Boonsongsawat, Waralee Asanawittaya, Anchalee Jintapattanakit, Doungdaw Chantasart, Amaraporn Wongrakpanich
• Other Authors: Mahidol University
• Format: Article
• Published: 2022
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/78820

Concentrated 7% w/w a-arbutin cream was formulated and evaluated using O/W and W/O emulsion bases as an extemporaneous preparation for melasma treatment. Cream bases were formulated with two pH values, 4.0 and 5.5, using a hot process. The stability of the creams was studied for 60 days under three...