Probing the anti-cancer potency of sulfated galactans on cholangiocarcinoma cells using synchrotron FTIR microspectroscopy, molecular docking, and in vitro studies

• Main Authors: Boonyakorn Boonsri, Kiattawee Choowongkomon, Buabarn Kuaprasert, Thanvarin Thitiphatphuvanon, Kittiya Supradit, Apinya Sayinta, Jinchutha Duangdara, Tawut Rudtanatip, Kanokpan Wongprasert
• Other Authors: Siam University
• Format: Article
• Published: 2022
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/78963
• Institution: Mahidol University

Sulfated galactans (SG) isolated from red alga Gracilaria fisheri have been reported to inhibit the growth of cholangiocarcinoma (CCA) cells, which was similar to the epidermal growth factor receptor (EGFR)-targeted drug, cetuximab. Herein, we studied the anti-cancer potency of SG compared to cetuxi...