Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations

Internationally, studies have shown associations between lipids and glycemia; however, whether the link varies by gender and population has been rarely examined. We investigated relationships between glycemia and HDL- and Non-HDL-cholesterol and their modification by gender. We undertook a cross-sec...

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Main Authors: Chaiwat Washirasaksiri, Weerachai Srivanichakorn, Ian F. Godsland, Chayanis Kositamongkol, Suwat Chariyalertsak, Pattapong Kessomboon, Sawitri Assanangkornchai, Surasak Taneepanichskul, Nareemarn Neelapaichit, Pochamana Phisalprapa, Desmond G. Johnston, Nick S. Oliver, Wichai Aekplakorn
Other Authors: Ramathibodi Hospital
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Published: 2022
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/79242
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spelling th-mahidol.792422022-08-04T18:38:35Z Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations Chaiwat Washirasaksiri Weerachai Srivanichakorn Ian F. Godsland Chayanis Kositamongkol Suwat Chariyalertsak Pattapong Kessomboon Sawitri Assanangkornchai Surasak Taneepanichskul Nareemarn Neelapaichit Pochamana Phisalprapa Desmond G. Johnston Nick S. Oliver Wichai Aekplakorn Ramathibodi Hospital Siriraj Hospital Chulalongkorn University Faculty of Medicine, Khon Kaen University Faculty of Medicine, Prince of Songkia University Imperial College Faculty of Medicine Faculty of Medicine Ramathibodi Hospital, Mahidol University Chiang Mai University Multidisciplinary Internationally, studies have shown associations between lipids and glycemia; however, whether the link varies by gender and population has been rarely examined. We investigated relationships between glycemia and HDL- and Non-HDL-cholesterol and their modification by gender. We undertook a cross-sectional analysis from the National Health Examination Survey for Thailand (NHES-Thailand) and the Health Survey for England (HS-England) in adults aged 18–75 year. Glycaemia was assessed by FPG in Thailand and by HbA1c in the UK. In population- and gender-stratified analyses, the relationships between glycemia and lipids were explored. A total of 15,145 Thai and 3484 UK adults with blood measurement were included. The prevalences of prediabetes were: in NHES-Thailand, 16% (SE = 0.004), based on FPG (5.6 to < 7.0 mmol/L) and in HS-England, 19% (0.007) based on HbA1c (39 to < 48 mmol/mol). Increasingly abnormal glucose homeostasis was associated with increasing age, adiposity, SBP, proportion of antihypertensive and lipid-lowering agent use and with decreasing HDL-cholesterol. Independent of age, adiposity, smoking, alcohol, physical activity, and lipid and BP lowering drug use, increasing glycemia was associated with decreasing HDL-cholesterol specifically in women with prediabetes (NHES-Thailand, beta-coefficient − 0.07 (95% CI − 0.15, − 0.001) p = 0.04 and HS-England, − 0.03 (− 0.04, − 0.006) p = 0.01). In both populations, among those with prediabetes, increasing glycaemia is associated with an adverse, significant decline in HDL cholesterol, specifically in women. These adverse effects are apparent in widely-differing international populations. 2022-08-04T11:38:35Z 2022-08-04T11:38:35Z 2021-12-01 Article Scientific Reports. Vol.11, No.1 (2021) 10.1038/s41598-021-91075-9 20452322 2-s2.0-85107432264 https://repository.li.mahidol.ac.th/handle/123456789/79242 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85107432264&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Multidisciplinary
spellingShingle Multidisciplinary
Chaiwat Washirasaksiri
Weerachai Srivanichakorn
Ian F. Godsland
Chayanis Kositamongkol
Suwat Chariyalertsak
Pattapong Kessomboon
Sawitri Assanangkornchai
Surasak Taneepanichskul
Nareemarn Neelapaichit
Pochamana Phisalprapa
Desmond G. Johnston
Nick S. Oliver
Wichai Aekplakorn
Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
description Internationally, studies have shown associations between lipids and glycemia; however, whether the link varies by gender and population has been rarely examined. We investigated relationships between glycemia and HDL- and Non-HDL-cholesterol and their modification by gender. We undertook a cross-sectional analysis from the National Health Examination Survey for Thailand (NHES-Thailand) and the Health Survey for England (HS-England) in adults aged 18–75 year. Glycaemia was assessed by FPG in Thailand and by HbA1c in the UK. In population- and gender-stratified analyses, the relationships between glycemia and lipids were explored. A total of 15,145 Thai and 3484 UK adults with blood measurement were included. The prevalences of prediabetes were: in NHES-Thailand, 16% (SE = 0.004), based on FPG (5.6 to < 7.0 mmol/L) and in HS-England, 19% (0.007) based on HbA1c (39 to < 48 mmol/mol). Increasingly abnormal glucose homeostasis was associated with increasing age, adiposity, SBP, proportion of antihypertensive and lipid-lowering agent use and with decreasing HDL-cholesterol. Independent of age, adiposity, smoking, alcohol, physical activity, and lipid and BP lowering drug use, increasing glycemia was associated with decreasing HDL-cholesterol specifically in women with prediabetes (NHES-Thailand, beta-coefficient − 0.07 (95% CI − 0.15, − 0.001) p = 0.04 and HS-England, − 0.03 (− 0.04, − 0.006) p = 0.01). In both populations, among those with prediabetes, increasing glycaemia is associated with an adverse, significant decline in HDL cholesterol, specifically in women. These adverse effects are apparent in widely-differing international populations.
author2 Ramathibodi Hospital
author_facet Ramathibodi Hospital
Chaiwat Washirasaksiri
Weerachai Srivanichakorn
Ian F. Godsland
Chayanis Kositamongkol
Suwat Chariyalertsak
Pattapong Kessomboon
Sawitri Assanangkornchai
Surasak Taneepanichskul
Nareemarn Neelapaichit
Pochamana Phisalprapa
Desmond G. Johnston
Nick S. Oliver
Wichai Aekplakorn
format Article
author Chaiwat Washirasaksiri
Weerachai Srivanichakorn
Ian F. Godsland
Chayanis Kositamongkol
Suwat Chariyalertsak
Pattapong Kessomboon
Sawitri Assanangkornchai
Surasak Taneepanichskul
Nareemarn Neelapaichit
Pochamana Phisalprapa
Desmond G. Johnston
Nick S. Oliver
Wichai Aekplakorn
author_sort Chaiwat Washirasaksiri
title Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
title_short Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
title_full Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
title_fullStr Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
title_full_unstemmed Increasing glycaemia is associated with a significant decline in HDL cholesterol in women with prediabetes in two national populations
title_sort increasing glycaemia is associated with a significant decline in hdl cholesterol in women with prediabetes in two national populations
publishDate 2022
url https://repository.li.mahidol.ac.th/handle/123456789/79242
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