Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases
Standard treatment for HIV infection involves a combination of antiretrovirals. Additionally, opportunistic infections in HIV infected patients require further antimicrobial medications that might cause drug-drug interactions (DDIs). The objective of this study was to to compare the recognition of D...
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th-mahidol.792582022-08-04T18:38:54Z Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases Pornpun Vivithanaporn Teetat Kongratanapasert Bovornpat Suriyapakorn Pichayut Songkunlertchai Patpicha Mongkonariyawong Patanachai K. Limpikirati Phisit Khemawoot Chulalongkorn University Faculty of Medicine Ramathibodi Hospital, Mahidol University Multidisciplinary Standard treatment for HIV infection involves a combination of antiretrovirals. Additionally, opportunistic infections in HIV infected patients require further antimicrobial medications that might cause drug-drug interactions (DDIs). The objective of this study was to to compare the recognition of DDIs between antiretrovirals and antimicrobials by three proprietary databases and evaluate their concordance. 114 items of antiretrovirals and antimicrobials from the National List of Essential Medicines of Thailand 2018 were used in the study. However, 21 items were not recognised by Micromedex, Drugs.com, and Liverpool HIV interactions. Only 93 items were available for the detection of potential DDIs by the three databases. Potential DDIs detected from the three databases included 292 pairs. Liverpool showed the highest number of DDIs with 285 pairs compared with 259 pairs by drugs.com and 133 pairs by Micromedex. Regarding the severity classifications, Liverpool reported 10% Contraindicated; Micromedex reported 14% contraindicated and 59% major; Drugs.com reported 21% major. The Fleiss’ kappa agreements were fair to poor among the three databases, higher agreement was observed for DDIs classified as severe. This study highlights the need to harmonize the evaluation and interpretation of DDI risk in order to produce standardized information to support prescribers. 2022-08-04T11:38:54Z 2022-08-04T11:38:54Z 2021-12-01 Article Scientific Reports. Vol.11, No.1 (2021) 10.1038/s41598-021-85586-8 20452322 2-s2.0-85102745737 https://repository.li.mahidol.ac.th/handle/123456789/79258 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85102745737&origin=inward |
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Multidisciplinary Pornpun Vivithanaporn Teetat Kongratanapasert Bovornpat Suriyapakorn Pichayut Songkunlertchai Patpicha Mongkonariyawong Patanachai K. Limpikirati Phisit Khemawoot Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases |
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Standard treatment for HIV infection involves a combination of antiretrovirals. Additionally, opportunistic infections in HIV infected patients require further antimicrobial medications that might cause drug-drug interactions (DDIs). The objective of this study was to to compare the recognition of DDIs between antiretrovirals and antimicrobials by three proprietary databases and evaluate their concordance. 114 items of antiretrovirals and antimicrobials from the National List of Essential Medicines of Thailand 2018 were used in the study. However, 21 items were not recognised by Micromedex, Drugs.com, and Liverpool HIV interactions. Only 93 items were available for the detection of potential DDIs by the three databases. Potential DDIs detected from the three databases included 292 pairs. Liverpool showed the highest number of DDIs with 285 pairs compared with 259 pairs by drugs.com and 133 pairs by Micromedex. Regarding the severity classifications, Liverpool reported 10% Contraindicated; Micromedex reported 14% contraindicated and 59% major; Drugs.com reported 21% major. The Fleiss’ kappa agreements were fair to poor among the three databases, higher agreement was observed for DDIs classified as severe. This study highlights the need to harmonize the evaluation and interpretation of DDI risk in order to produce standardized information to support prescribers. |
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Chulalongkorn University |
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Chulalongkorn University Pornpun Vivithanaporn Teetat Kongratanapasert Bovornpat Suriyapakorn Pichayut Songkunlertchai Patpicha Mongkonariyawong Patanachai K. Limpikirati Phisit Khemawoot |
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Article |
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Pornpun Vivithanaporn Teetat Kongratanapasert Bovornpat Suriyapakorn Pichayut Songkunlertchai Patpicha Mongkonariyawong Patanachai K. Limpikirati Phisit Khemawoot |
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Pornpun Vivithanaporn |
title |
Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases |
title_short |
Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases |
title_full |
Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases |
title_fullStr |
Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases |
title_full_unstemmed |
Potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases |
title_sort |
potential drug-drug interactions of antiretrovirals and antimicrobials detected by three databases |
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2022 |
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https://repository.li.mahidol.ac.th/handle/123456789/79258 |
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