Genetic Determinants of Response to Warfarin in Thai Patients

• Main Authors: Parichat Sittinateskul, Pantep Angchaisuksiri, Werasak Sasanakul, Ampaiwan Chuansumrit, ปริฉัตร์ สิทธิเนตรสกุล, พันธ์ุเทพ อังชัยสุขศิริ, วีระศักดิ์ ศาสนกุล, อำไพวรรณ จวนสัมฤทธิ์
• Other Authors: Mahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Medicine
• Format: Original Article
• Language: English
• Published: 2022
• Subjects: Warfarin; VKORC1; CYP2C9; Thai
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/79903
• Institution: Mahidol University

Background: Genetic variants of the enzyme that metabolizes warfarin, cytochrome P 450 2C9 (CYP2C9), and of a key pharmacologic target of warfarin, vitamin K epoxide reductase (VKORC1), contribute to differences in patients’ responses to various warfarin doses, but the role of these variants in Thai...