Mitochondria-derived vesicles and their potential roles in kidney stone disease
Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be...
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th-mahidol.815322023-05-19T14:29:08Z Mitochondria-derived vesicles and their potential roles in kidney stone disease Chaiyarit S. Mahidol University Biochemistry, Genetics and Molecular Biology Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be eliminated to restore normal mitochondrial structure and functions. Under severe oxidative stress condition, mitochondrial dynamics (fission/fusion) and mitophagy are predominantly activated to rescue mitochondrial structure and functions. Additionally, MDVs generation can be also triggered as the major MQC machinery to cope with unhealthy mitochondria when mitophagy is unsuccessful for eliminating the damaged mitochondria or mitochondrial fission/fusion fail to recover the mitochondrial structure and functions. This review summarizes the current knowledge on MDVs and discuss their roles in physiologic and pathophysiologic conditions. In addition, the potential clinical relevance of MDVs in therapeutics and diagnostics of kidney stone disease (KSD) are emphasized. 2023-05-19T07:29:08Z 2023-05-19T07:29:08Z 2023-12-01 Review Journal of Translational Medicine Vol.21 No.1 (2023) 10.1186/s12967-023-04133-3 14795876 37131163 2-s2.0-85157976173 https://repository.li.mahidol.ac.th/handle/123456789/81532 SCOPUS |
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Biochemistry, Genetics and Molecular Biology Chaiyarit S. Mitochondria-derived vesicles and their potential roles in kidney stone disease |
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Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be eliminated to restore normal mitochondrial structure and functions. Under severe oxidative stress condition, mitochondrial dynamics (fission/fusion) and mitophagy are predominantly activated to rescue mitochondrial structure and functions. Additionally, MDVs generation can be also triggered as the major MQC machinery to cope with unhealthy mitochondria when mitophagy is unsuccessful for eliminating the damaged mitochondria or mitochondrial fission/fusion fail to recover the mitochondrial structure and functions. This review summarizes the current knowledge on MDVs and discuss their roles in physiologic and pathophysiologic conditions. In addition, the potential clinical relevance of MDVs in therapeutics and diagnostics of kidney stone disease (KSD) are emphasized. |
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Mahidol University |
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Mahidol University Chaiyarit S. |
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Review |
author |
Chaiyarit S. |
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Chaiyarit S. |
title |
Mitochondria-derived vesicles and their potential roles in kidney stone disease |
title_short |
Mitochondria-derived vesicles and their potential roles in kidney stone disease |
title_full |
Mitochondria-derived vesicles and their potential roles in kidney stone disease |
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Mitochondria-derived vesicles and their potential roles in kidney stone disease |
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Mitochondria-derived vesicles and their potential roles in kidney stone disease |
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mitochondria-derived vesicles and their potential roles in kidney stone disease |
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2023 |
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https://repository.li.mahidol.ac.th/handle/123456789/81532 |
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