Factors Related to Club Cell Protein 16 (CC16) and Quality of Life in Northern Thailand

• Main Author: Nangola S.
• Other Authors: Mahidol University
• Format: Article
• Published: 2023
• Subjects: Environmental Science
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/81886

Exposure to poor air quality can cause adverse health effects, especially club cell protein 16 (CC16) as potential marker for a lung injury, and a reduced quality of life (QoL). This study aimed to evaluate factors related to CC16 and QoL among people living near the air quality monitoring stations in Northern Thailand. A cross-sectional study was conducted. A total of 240 individuals were recruited. Data was collected using structured 36-item short-form survey (SF-36) questionnaires. Air quality was measured using air quality monitoring stations by the Pollution Control Department (PCD), Thailand. Diseases and related health problems were defined using the International Classification of Diseases ICD-10) by the Information and Communication Technology Center, Thailand. Venous blood was collected and analyzed for serum CC16 by medical laboratory technicians. The daily PM10 and PM2.5 concentrations were significantly positively associated with I00-I99 and J00-J99.8. The mean ± SD of serum CC16 levels in participants under 60 years old was 5.33 ± 4.24 ng/ml, which was significantly lower than 10.01 ± 6.91 ng/ml in participants 60 years and older (p value < 0.001). The serum CC16 level was significantly associated with physical health (PH), mental health (MH), and overall QoL. Multiple linear regression analysis showed that an increase in serum CC16 level was associated with a decrease in overall QoL after adjusting for confounding variables. Concerned agencies should provide policymakers and health promotion interventions for reducing pollution exposure and self-protective behaviors to prevent airway inflammatory responses, chronic respiratory diseases, and poor QoL.