Factors associated with false-negative for T-SPOT.TB in patients with TB disease
BACKGROUND:: T-SPOT.TB is an adjunctive diagnostic tool that is used for detecting TB disease. However, in some patients with TB disease, a false-negative result can occur. This study aims to determine the factors that are associated with false-negative T-SPOT.TB results in TB disease.METHODS:: We r...
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th-mahidol.824032023-05-19T15:24:19Z Factors associated with false-negative for T-SPOT.TB in patients with TB disease Tochaeng C. Mahidol University Medicine BACKGROUND:: T-SPOT.TB is an adjunctive diagnostic tool that is used for detecting TB disease. However, in some patients with TB disease, a false-negative result can occur. This study aims to determine the factors that are associated with false-negative T-SPOT.TB results in TB disease.METHODS:: We retrospectively enrolled 210 patients who were diagnosed with TB disease and underwent T-SPOT.TB testing between July 2014 and July 2020 at Ramathibodi Hospital Bangkok, Thailand. Clinical characteristics, laboratory findings and radiographic findings were compared between the false-negative and true-positive T-SPOT.TB groups.RESULTS:: Among 210 patients with TB disease, 144 patients had pulmonary TB, 44 patients had extrapulmonary TB and 22 patients had concomitant pulmonary and extrapulmonary TB. There were 100 male and 110 female patients, with a mean age of 54.1 ± 17.5 years. Ninety patients (42.9%) had false-negative T-SPOT.TB results. Multivariate analysis showed that increased age was significantly associated with false-negative T-SPOT.TB (OR 1.025, 95% CI 1.008-1.043, P = 0.006). Those aged ≥55 years had 1.8 times higher false-negative T-SPOT.TB rate than the younger group (age ≥55 years: 64.4% vs. age <55 years: 35.6%; P = 0.001).CONCLUSION:: Advanced age, particularly age ≥55 years, was a significant factor that related with false-negative T-SPOT.TB results in TB disease. 2023-05-19T08:24:19Z 2023-05-19T08:24:19Z 2023-02-01 Article The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Vol.27 No.2 (2023) , 128-134 10.5588/ijtld.22.0368 18157920 36853117 2-s2.0-85149154029 https://repository.li.mahidol.ac.th/handle/123456789/82403 SCOPUS |
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Medicine Tochaeng C. Factors associated with false-negative for T-SPOT.TB in patients with TB disease |
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BACKGROUND:: T-SPOT.TB is an adjunctive diagnostic tool that is used for detecting TB disease. However, in some patients with TB disease, a false-negative result can occur. This study aims to determine the factors that are associated with false-negative T-SPOT.TB results in TB disease.METHODS:: We retrospectively enrolled 210 patients who were diagnosed with TB disease and underwent T-SPOT.TB testing between July 2014 and July 2020 at Ramathibodi Hospital Bangkok, Thailand. Clinical characteristics, laboratory findings and radiographic findings were compared between the false-negative and true-positive T-SPOT.TB groups.RESULTS:: Among 210 patients with TB disease, 144 patients had pulmonary TB, 44 patients had extrapulmonary TB and 22 patients had concomitant pulmonary and extrapulmonary TB. There were 100 male and 110 female patients, with a mean age of 54.1 ± 17.5 years. Ninety patients (42.9%) had false-negative T-SPOT.TB results. Multivariate analysis showed that increased age was significantly associated with false-negative T-SPOT.TB (OR 1.025, 95% CI 1.008-1.043, P = 0.006). Those aged ≥55 years had 1.8 times higher false-negative T-SPOT.TB rate than the younger group (age ≥55 years: 64.4% vs. age <55 years: 35.6%; P = 0.001).CONCLUSION:: Advanced age, particularly age ≥55 years, was a significant factor that related with false-negative T-SPOT.TB results in TB disease. |
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Mahidol University Tochaeng C. |
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Tochaeng C. |
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Tochaeng C. |
title |
Factors associated with false-negative for T-SPOT.TB in patients with TB disease |
title_short |
Factors associated with false-negative for T-SPOT.TB in patients with TB disease |
title_full |
Factors associated with false-negative for T-SPOT.TB in patients with TB disease |
title_fullStr |
Factors associated with false-negative for T-SPOT.TB in patients with TB disease |
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Factors associated with false-negative for T-SPOT.TB in patients with TB disease |
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factors associated with false-negative for t-spot.tb in patients with tb disease |
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2023 |
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https://repository.li.mahidol.ac.th/handle/123456789/82403 |
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1781415869098754048 |