The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase
Dengue and Zika viruses are mosquito-borne flaviviruses burdening millions every year with hemorrhagic fever and neurological symptoms. Baicalein was previously reported as a potential anti-flaviviral candidate and halogenation of flavones and flavanones potentiated their antiviral efficacies. Here,...
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th-mahidol.827972023-05-25T00:20:50Z The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase Boonyasuppayakorn S. Mahidol University Multidisciplinary Dengue and Zika viruses are mosquito-borne flaviviruses burdening millions every year with hemorrhagic fever and neurological symptoms. Baicalein was previously reported as a potential anti-flaviviral candidate and halogenation of flavones and flavanones potentiated their antiviral efficacies. Here, we reported that a chemically modified 8-bromobaicalein effectively inhibited all dengue serotypes and Zika viruses at 0.66–0.88 micromolar in cell-based system. The compound bound to dengue serotype 2 conserved pocket and inhibited the dengue RdRp activity with 6.93 fold more than the original baicalein. Moreover, the compound was mildly toxic against infant and adult C57BL/6 mice despite administering continuously for 7 days. Therefore, the 8-bromobaicalein should be investigated further in pharmacokinetics and efficacy in an animal model. 2023-05-24T17:20:50Z 2023-05-24T17:20:50Z 2023-12-01 Article Scientific Reports Vol.13 No.1 (2023) 10.1038/s41598-023-32049-x 20452322 36966240 2-s2.0-85150991033 https://repository.li.mahidol.ac.th/handle/123456789/82797 SCOPUS |
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Multidisciplinary Boonyasuppayakorn S. The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase |
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Dengue and Zika viruses are mosquito-borne flaviviruses burdening millions every year with hemorrhagic fever and neurological symptoms. Baicalein was previously reported as a potential anti-flaviviral candidate and halogenation of flavones and flavanones potentiated their antiviral efficacies. Here, we reported that a chemically modified 8-bromobaicalein effectively inhibited all dengue serotypes and Zika viruses at 0.66–0.88 micromolar in cell-based system. The compound bound to dengue serotype 2 conserved pocket and inhibited the dengue RdRp activity with 6.93 fold more than the original baicalein. Moreover, the compound was mildly toxic against infant and adult C57BL/6 mice despite administering continuously for 7 days. Therefore, the 8-bromobaicalein should be investigated further in pharmacokinetics and efficacy in an animal model. |
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Mahidol University |
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Mahidol University Boonyasuppayakorn S. |
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Boonyasuppayakorn S. |
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Boonyasuppayakorn S. |
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The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase |
title_short |
The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase |
title_full |
The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase |
title_fullStr |
The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase |
title_full_unstemmed |
The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase |
title_sort |
8-bromobaicalein inhibited the replication of dengue, and zika viruses and targeted the dengue polymerase |
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2023 |
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https://repository.li.mahidol.ac.th/handle/123456789/82797 |
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