Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells
O’nyongnyong virus (ONNV) is a re-emerging alphavirus previously known to be transmitted by main malaria vectors, thus suggesting the possibility of coinfections with arboviruses in co-endemic areas. However, the pathological outcomes of such infections remain unknown. Using murine coinfection model...
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th-mahidol.832932023-06-18T23:37:29Z Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells Torres-Ruesta A. Mahidol University Agricultural and Biological Sciences O’nyongnyong virus (ONNV) is a re-emerging alphavirus previously known to be transmitted by main malaria vectors, thus suggesting the possibility of coinfections with arboviruses in co-endemic areas. However, the pathological outcomes of such infections remain unknown. Using murine coinfection models, we demonstrated that a preexisting blood-stage Plasmodium infection suppresses ONNV-induced pathologies. We further showed that suppression of viremia and virus dissemination are dependent on Plasmodium-induced IFNγ and are associated with reduced infection of CD452 cells at the site of virus inoculation. We further proved that treatment with IFNγ or plasma samples from Plasmodium vivax–infected patients containing IFNγ are able to restrict ONNV infection in human fibroblast, synoviocyte, skeletal muscle, and endothelial cell lines. Mechanistically, the role of IFNγ in restricting ONNV infection was confirmed in in vitro infection assays through the generation of an IFNγ receptor 1 α chain (IFNγR1)–deficient cell line. 2023-06-18T16:37:29Z 2023-06-18T16:37:29Z 2022-04-01 Article Life Science Alliance Vol.5 No.4 (2022) 10.26508/lsa.202101272 25751077 35039441 2-s2.0-85123568157 https://repository.li.mahidol.ac.th/handle/123456789/83293 SCOPUS |
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Agricultural and Biological Sciences Torres-Ruesta A. Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells |
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O’nyongnyong virus (ONNV) is a re-emerging alphavirus previously known to be transmitted by main malaria vectors, thus suggesting the possibility of coinfections with arboviruses in co-endemic areas. However, the pathological outcomes of such infections remain unknown. Using murine coinfection models, we demonstrated that a preexisting blood-stage Plasmodium infection suppresses ONNV-induced pathologies. We further showed that suppression of viremia and virus dissemination are dependent on Plasmodium-induced IFNγ and are associated with reduced infection of CD452 cells at the site of virus inoculation. We further proved that treatment with IFNγ or plasma samples from Plasmodium vivax–infected patients containing IFNγ are able to restrict ONNV infection in human fibroblast, synoviocyte, skeletal muscle, and endothelial cell lines. Mechanistically, the role of IFNγ in restricting ONNV infection was confirmed in in vitro infection assays through the generation of an IFNγ receptor 1 α chain (IFNγR1)–deficient cell line. |
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Mahidol University |
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Mahidol University Torres-Ruesta A. |
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Torres-Ruesta A. |
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Torres-Ruesta A. |
title |
Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells |
title_short |
Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells |
title_full |
Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells |
title_fullStr |
Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells |
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Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells |
title_sort |
malaria abrogates o’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells |
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2023 |
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https://repository.li.mahidol.ac.th/handle/123456789/83293 |
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