Targeting the Ubiquinol-Reduction (Q<inf>i</inf>) Site of the Mitochondrial Cytochrome bc<inf>1</inf> Complex for the Development of Next Generation Quinolone Antimalarials
Antimalarials targeting the ubiquinol-oxidation (Qo) site of the Plasmodium falciparum bc1 complex, such as atovaquone, have become less effective due to the rapid emergence of resistance linked to point mutations in the Qo site. Recent findings showed a series of 2-aryl quinolones mediate inhibitio...
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| Format: | Article |
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2023
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| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/83640 |
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| Institution: | Mahidol University |