Causal association pathways between fetuin-A and kidney function: a mediation analysis
Objective: Body mass index (BMI), uric acid, diabetes mellitus, and hypertension are risk factors for reduced kidney function and are associated with fetuin-A levels, but their causal pathways remain unclear. The objective of this study was to investigate this knowledge gap. Methods: A repeated cros...
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th-mahidol.837722023-06-18T23:48:13Z Causal association pathways between fetuin-A and kidney function: a mediation analysis Bassey P.E. Mahidol University Biochemistry, Genetics and Molecular Biology Objective: Body mass index (BMI), uric acid, diabetes mellitus, and hypertension are risk factors for reduced kidney function and are associated with fetuin-A levels, but their causal pathways remain unclear. The objective of this study was to investigate this knowledge gap. Methods: A repeated cross-sectional design was used to assess causal pathway effects of fetuin-A on the estimated glomerular filtration rate (eGFR), which is mediated through BMI, uric acid, diabetes mellitus, and hypertension. Results: Among 2305 participants, the mean eGFR at baseline decreased from 98.7 ± 23.6 mL/minute/1.73 m2 in 2009 to 92.4 ± 22.9 mL/minute/1.73 m2 in 2014. Fetuin-A was significantly associated with eGFR, suggesting that increasing fetuin-A levels predict a decrease in eGFR. Additionally, the indirect effect of fetuin-A on eGFR, as assessed through BMI, was also significant. The effects of fetuin-A on eGFR through other mediation pathways showed variable results. Conclusions: Our study revealed a possible role of fetuin-A in the etiology of declining renal function through mediating body mass index, uric acid, diabetes mellitus, and hypertension via complex causal pathways. Further studies to clarify these mediated effects are recommended. 2023-06-18T16:48:13Z 2023-06-18T16:48:13Z 2022-04-01 Article Journal of International Medical Research Vol.50 No.4 (2022) 10.1177/03000605221082874 14732300 03000605 35435033 2-s2.0-85128434943 https://repository.li.mahidol.ac.th/handle/123456789/83772 SCOPUS |
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Biochemistry, Genetics and Molecular Biology Bassey P.E. Causal association pathways between fetuin-A and kidney function: a mediation analysis |
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Objective: Body mass index (BMI), uric acid, diabetes mellitus, and hypertension are risk factors for reduced kidney function and are associated with fetuin-A levels, but their causal pathways remain unclear. The objective of this study was to investigate this knowledge gap. Methods: A repeated cross-sectional design was used to assess causal pathway effects of fetuin-A on the estimated glomerular filtration rate (eGFR), which is mediated through BMI, uric acid, diabetes mellitus, and hypertension. Results: Among 2305 participants, the mean eGFR at baseline decreased from 98.7 ± 23.6 mL/minute/1.73 m2 in 2009 to 92.4 ± 22.9 mL/minute/1.73 m2 in 2014. Fetuin-A was significantly associated with eGFR, suggesting that increasing fetuin-A levels predict a decrease in eGFR. Additionally, the indirect effect of fetuin-A on eGFR, as assessed through BMI, was also significant. The effects of fetuin-A on eGFR through other mediation pathways showed variable results. Conclusions: Our study revealed a possible role of fetuin-A in the etiology of declining renal function through mediating body mass index, uric acid, diabetes mellitus, and hypertension via complex causal pathways. Further studies to clarify these mediated effects are recommended. |
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Mahidol University |
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Mahidol University Bassey P.E. |
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Bassey P.E. |
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Bassey P.E. |
title |
Causal association pathways between fetuin-A and kidney function: a mediation analysis |
title_short |
Causal association pathways between fetuin-A and kidney function: a mediation analysis |
title_full |
Causal association pathways between fetuin-A and kidney function: a mediation analysis |
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Causal association pathways between fetuin-A and kidney function: a mediation analysis |
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Causal association pathways between fetuin-A and kidney function: a mediation analysis |
title_sort |
causal association pathways between fetuin-a and kidney function: a mediation analysis |
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2023 |
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https://repository.li.mahidol.ac.th/handle/123456789/83772 |
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