Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review
Background: Studies have demonstrated the link between vitamin-D-related genetic variations and nonskeletal outcomes. We aimed to identify all available data on the association of vitamin-D-related genetic variations with nonalcoholic fatty liver disease (NAFLD). Methods: Potentially eligible studie...
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th-mahidol.840662023-06-18T23:54:34Z Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review Jaroenlapnopparat A. Mahidol University Chemical Engineering Background: Studies have demonstrated the link between vitamin-D-related genetic variations and nonskeletal outcomes. We aimed to identify all available data on the association of vitamin-D-related genetic variations with nonalcoholic fatty liver disease (NAFLD). Methods: Potentially eligible studies were identified from Embase and Medline databases from inception to June 2022 using a search strategy that comprised terms for “Vitamin D” and “NAFLD”. Eligible studies must report the association between vitamin D-related genetic variations and presence, severity or response to treatment of NAFLD. Data were extracted from each eligible study. Results: A total of 3495 articles were identified. After a systematic review, twelve studies were included. A total of 26 genetic variations were identified. Presence of NAFLD was associated with variations of GC (rs222054, rs222020, rs10011000, rs7041), VDR (rs2228570, rs11168287, rs10783219, rs4752), CYP24A1 (rs3787557, rs6068816, rs2296241, rs2248359) and CYP27B1 (rs4646536). Severity of NAFLD was associated with variations of GC (rs4588), VDR (rs2228570, rs4334089), CYP2R1 (rs10741657), DHCR7 (rs1544410, rs3829251, rs12785878) and CYP24A1 (rs3787557, rs6068816, rs6097809, rs6127119, rs2248359, rs3787554, rs4809960, rs6022999). Response to calcitriol treatment was associated with variation of VDR (rs10735810). Conclusions: Multiple vitamin D-related genetic variations were associated with NAFLD, indicating the role of vitamin D in the pathogenesis of NAFLD. 2023-06-18T16:54:34Z 2023-06-18T16:54:34Z 2022-08-01 Review International Journal of Molecular Sciences Vol.23 No.16 (2022) 10.3390/ijms23169122 14220067 16616596 36012386 2-s2.0-85136687009 https://repository.li.mahidol.ac.th/handle/123456789/84066 SCOPUS |
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Chemical Engineering Jaroenlapnopparat A. Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review |
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Background: Studies have demonstrated the link between vitamin-D-related genetic variations and nonskeletal outcomes. We aimed to identify all available data on the association of vitamin-D-related genetic variations with nonalcoholic fatty liver disease (NAFLD). Methods: Potentially eligible studies were identified from Embase and Medline databases from inception to June 2022 using a search strategy that comprised terms for “Vitamin D” and “NAFLD”. Eligible studies must report the association between vitamin D-related genetic variations and presence, severity or response to treatment of NAFLD. Data were extracted from each eligible study. Results: A total of 3495 articles were identified. After a systematic review, twelve studies were included. A total of 26 genetic variations were identified. Presence of NAFLD was associated with variations of GC (rs222054, rs222020, rs10011000, rs7041), VDR (rs2228570, rs11168287, rs10783219, rs4752), CYP24A1 (rs3787557, rs6068816, rs2296241, rs2248359) and CYP27B1 (rs4646536). Severity of NAFLD was associated with variations of GC (rs4588), VDR (rs2228570, rs4334089), CYP2R1 (rs10741657), DHCR7 (rs1544410, rs3829251, rs12785878) and CYP24A1 (rs3787557, rs6068816, rs6097809, rs6127119, rs2248359, rs3787554, rs4809960, rs6022999). Response to calcitriol treatment was associated with variation of VDR (rs10735810). Conclusions: Multiple vitamin D-related genetic variations were associated with NAFLD, indicating the role of vitamin D in the pathogenesis of NAFLD. |
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Mahidol University |
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Mahidol University Jaroenlapnopparat A. |
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Jaroenlapnopparat A. |
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Jaroenlapnopparat A. |
title |
Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review |
title_short |
Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review |
title_full |
Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review |
title_fullStr |
Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review |
title_full_unstemmed |
Vitamin D-Related Genetic Variations and Nonalcoholic Fatty Liver Disease: A Systematic Review |
title_sort |
vitamin d-related genetic variations and nonalcoholic fatty liver disease: a systematic review |
publishDate |
2023 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/84066 |
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1781416275091652608 |