Direct Synthesis of Coumarin Derivatives from Alkynoic Esters via Dual Organocatalysis

An efficient synthetic method for coumarin derivatives was developed using a dual organocatalytic reaction. A combination of ptoluenesulfonic acid monohydrate and piperidine was found to efficiently catalyze the cyclization between salicylaldehydes and alkynoic esters to give various coumarin deriva...

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Main Author:	Saejong P.
Other Authors:	Mahidol University
Format:	Article
Published:	2023
Subjects:	Chemistry
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/84170
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Institution:	Mahidol University

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spelling	th-mahidol.841702023-06-18T23:57:55Z Direct Synthesis of Coumarin Derivatives from Alkynoic Esters via Dual Organocatalysis Saejong P. Mahidol University Chemistry An efficient synthetic method for coumarin derivatives was developed using a dual organocatalytic reaction. A combination of ptoluenesulfonic acid monohydrate and piperidine was found to efficiently catalyze the cyclization between salicylaldehydes and alkynoic esters to give various coumarin derivatives in good yield and high selectivity. Mechanistic and kinetic data suggested that the conjugate addition between piperidine and alkynoic esters played a crucial role in the reaction mechanism. 2023-06-18T16:57:55Z 2023-06-18T16:57:55Z 2022-09-01 Article Synlett Vol.33 No.14 (2022) , 1399-1404 10.1055/a-1797-0386 14372096 09365214 2-s2.0-85128178753 https://repository.li.mahidol.ac.th/handle/123456789/84170 SCOPUS
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Chemistry
spellingShingle	Chemistry Saejong P. Direct Synthesis of Coumarin Derivatives from Alkynoic Esters via Dual Organocatalysis
description	An efficient synthetic method for coumarin derivatives was developed using a dual organocatalytic reaction. A combination of ptoluenesulfonic acid monohydrate and piperidine was found to efficiently catalyze the cyclization between salicylaldehydes and alkynoic esters to give various coumarin derivatives in good yield and high selectivity. Mechanistic and kinetic data suggested that the conjugate addition between piperidine and alkynoic esters played a crucial role in the reaction mechanism.
author2	Mahidol University
author_facet	Mahidol University Saejong P.
format	Article
author	Saejong P.
author_sort	Saejong P.
title	Direct Synthesis of Coumarin Derivatives from Alkynoic Esters via Dual Organocatalysis
title_short	Direct Synthesis of Coumarin Derivatives from Alkynoic Esters via Dual Organocatalysis
title_full	Direct Synthesis of Coumarin Derivatives from Alkynoic Esters via Dual Organocatalysis
title_fullStr	Direct Synthesis of Coumarin Derivatives from Alkynoic Esters via Dual Organocatalysis
title_full_unstemmed	Direct Synthesis of Coumarin Derivatives from Alkynoic Esters via Dual Organocatalysis
title_sort	direct synthesis of coumarin derivatives from alkynoic esters via dual organocatalysis
publishDate	2023
url	https://repository.li.mahidol.ac.th/handle/123456789/84170
_version_	1781413975213211648

Direct Synthesis of Coumarin Derivatives from Alkynoic Esters via Dual Organocatalysis

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