Nitration of N-acetyl anilides using silver(I) nitrate/persulfate combination
Nitration of N-acetyl anilides using a simple combination of AgNO3 and K2S2O8 as a stable nitro source and an oxidant, respectively, was explored. The reaction was practical to operate and proceeded under considerably mild reaction conditions (reflux in acetonitrile) within acceptable reaction time...
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th-mahidol.842192023-06-18T23:59:36Z Nitration of N-acetyl anilides using silver(I) nitrate/persulfate combination Sanjeam H. Mahidol University Chemistry Nitration of N-acetyl anilides using a simple combination of AgNO3 and K2S2O8 as a stable nitro source and an oxidant, respectively, was explored. The reaction was practical to operate and proceeded under considerably mild reaction conditions (reflux in acetonitrile) within acceptable reaction time (6 h). The para-substituted N-acetyl anilides gave only ortho-nitrated products in moderate to good yields (30–63% yields). The ortho-, meta-, or non-substituted N-acetyl anilides gave a mixture of nitrated products (30–72% combined yields) with preferentially at the para- over the ortho-position (ortho:para; 1.0:1.1–1.0:2.8). 2023-06-18T16:59:36Z 2023-06-18T16:59:36Z 2022-01-01 Article Synthetic Communications Vol.52 No.9-10 (2022) , 1279-1289 10.1080/00397911.2022.2081924 15322432 00397911 2-s2.0-85131563495 https://repository.li.mahidol.ac.th/handle/123456789/84219 SCOPUS |
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Thailand Thailand |
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Chemistry |
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Chemistry Sanjeam H. Nitration of N-acetyl anilides using silver(I) nitrate/persulfate combination |
| description |
Nitration of N-acetyl anilides using a simple combination of AgNO3 and K2S2O8 as a stable nitro source and an oxidant, respectively, was explored. The reaction was practical to operate and proceeded under considerably mild reaction conditions (reflux in acetonitrile) within acceptable reaction time (6 h). The para-substituted N-acetyl anilides gave only ortho-nitrated products in moderate to good yields (30–63% yields). The ortho-, meta-, or non-substituted N-acetyl anilides gave a mixture of nitrated products (30–72% combined yields) with preferentially at the para- over the ortho-position (ortho:para; 1.0:1.1–1.0:2.8). |
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Mahidol University |
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Mahidol University Sanjeam H. |
| format |
Article |
| author |
Sanjeam H. |
| author_sort |
Sanjeam H. |
| title |
Nitration of N-acetyl anilides using silver(I) nitrate/persulfate combination |
| title_short |
Nitration of N-acetyl anilides using silver(I) nitrate/persulfate combination |
| title_full |
Nitration of N-acetyl anilides using silver(I) nitrate/persulfate combination |
| title_fullStr |
Nitration of N-acetyl anilides using silver(I) nitrate/persulfate combination |
| title_full_unstemmed |
Nitration of N-acetyl anilides using silver(I) nitrate/persulfate combination |
| title_sort |
nitration of n-acetyl anilides using silver(i) nitrate/persulfate combination |
| publishDate |
2023 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/84219 |
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1781414195206553600 |