Large Mammary Paget Disease without Underlying Breast Carcinoma

Mammary Paget disease is an uncommon type of breast cancer. Redness, scaling, and thickness involving the nipple and areola are common clinical symptoms. Invasive breast cancer was found in nearly 90% of these patients. Only a few cases of mammary Paget disease with no underlying cancer have been de...

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Main Author: Chirappapha P.
Other Authors: Mahidol University
Format: Article
Published: 2023
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/85449
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spelling th-mahidol.854492023-06-19T00:41:59Z Large Mammary Paget Disease without Underlying Breast Carcinoma Chirappapha P. Mahidol University Medicine Mammary Paget disease is an uncommon type of breast cancer. Redness, scaling, and thickness involving the nipple and areola are common clinical symptoms. Invasive breast cancer was found in nearly 90% of these patients. Only a few cases of mammary Paget disease with no underlying cancer have been described, with a better prognosis. Treatment options include wide excision or mastectomy. However, if the lesion is very extensive, breast reconstruction may be required. We reported a rare case of extensive Paget disease in a 65-year-old woman who had a 7-year history of a 14 × 19 cm progressively enlarging erythematous scaling lesion that covered her entire left breast. No evidence of related malignancy or metastatic lesion was seen. A left mastectomy with sentinel lymph node biopsy and immediate pedicled transverse rectus abdominis myocutaneous flap reconstruction was chosen. There is uncertainty about axillary node metastasis since multiple enlarged and palpable left axillary lymph nodes were seen. She had axillary lymph node dissection instead. A histological examination confirmed the diagnosis of Paget disease of the nipple in the absence of underlying breast cancer and there was no evidence of axillary lymph node metastasis. This article emphasizes the need to pay close attention to diagnosis, progression, and treatment of the disease. 2023-06-18T17:41:59Z 2023-06-18T17:41:59Z 2022-10-17 Article Plastic and Reconstructive Surgery - Global Open Vol.10 No.10 (2022) , E4606 10.1097/GOX.0000000000004606 21697574 2-s2.0-85141491987 https://repository.li.mahidol.ac.th/handle/123456789/85449 SCOPUS
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Chirappapha P.
Large Mammary Paget Disease without Underlying Breast Carcinoma
description Mammary Paget disease is an uncommon type of breast cancer. Redness, scaling, and thickness involving the nipple and areola are common clinical symptoms. Invasive breast cancer was found in nearly 90% of these patients. Only a few cases of mammary Paget disease with no underlying cancer have been described, with a better prognosis. Treatment options include wide excision or mastectomy. However, if the lesion is very extensive, breast reconstruction may be required. We reported a rare case of extensive Paget disease in a 65-year-old woman who had a 7-year history of a 14 × 19 cm progressively enlarging erythematous scaling lesion that covered her entire left breast. No evidence of related malignancy or metastatic lesion was seen. A left mastectomy with sentinel lymph node biopsy and immediate pedicled transverse rectus abdominis myocutaneous flap reconstruction was chosen. There is uncertainty about axillary node metastasis since multiple enlarged and palpable left axillary lymph nodes were seen. She had axillary lymph node dissection instead. A histological examination confirmed the diagnosis of Paget disease of the nipple in the absence of underlying breast cancer and there was no evidence of axillary lymph node metastasis. This article emphasizes the need to pay close attention to diagnosis, progression, and treatment of the disease.
author2 Mahidol University
author_facet Mahidol University
Chirappapha P.
format Article
author Chirappapha P.
author_sort Chirappapha P.
title Large Mammary Paget Disease without Underlying Breast Carcinoma
title_short Large Mammary Paget Disease without Underlying Breast Carcinoma
title_full Large Mammary Paget Disease without Underlying Breast Carcinoma
title_fullStr Large Mammary Paget Disease without Underlying Breast Carcinoma
title_full_unstemmed Large Mammary Paget Disease without Underlying Breast Carcinoma
title_sort large mammary paget disease without underlying breast carcinoma
publishDate 2023
url https://repository.li.mahidol.ac.th/handle/123456789/85449
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