In Vitro Antifungal Activity of Plain Socks and Zinc Oxide Nanoparticle-Coated Socks

BACKGROUND: Fungal foot infection is a common superficial fungal infection and is recognized as an important public health problem. Related to the wearing of occlusive footwear, foot infection is usually caused by dermatophytes and nondermatophyte molds. Previous in vitro studies have demonstrated t...

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Main Author: Prasong W.
Other Authors: Mahidol University
Format: Article
Published: 2023
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/86027
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spelling th-mahidol.860272023-06-19T00:53:33Z In Vitro Antifungal Activity of Plain Socks and Zinc Oxide Nanoparticle-Coated Socks Prasong W. Mahidol University Medicine BACKGROUND: Fungal foot infection is a common superficial fungal infection and is recognized as an important public health problem. Related to the wearing of occlusive footwear, foot infection is usually caused by dermatophytes and nondermatophyte molds. Previous in vitro studies have demonstrated that zinc oxide nanoparticles (ZnO-NPs) have antimicrobial activity against fungi. This study, therefore, evaluated the ability of socks coated with ZnO-NPs to inhibit fungal growth in an in vitro model mimicking real-life situations. METHODS: Scale from patients with fungal foot infections was equally divided into three groups: control, plain socks, and ZnO-NP socks. The specimens in the control group were routinely fungal cultured, whereas in the plain sock and ZnO-NP sock groups, scale was incubated with plain socks and ZnO-NP socks, respectively, for 24 hours. After incubation, each piece of sock was cultured. The fungal culture results of the three groups were progressively evaluated for 4 weeks. RESULTS: From 31 specimens, the positive fungal culture results of the control, plain sock, and ZnO-NP sock groups were 100%, 64.5%, and 54.8%, respectively. Specimens incubated with plain socks (P = .001) or with ZnO-NP socks (P < .001) had a significant reduction in the number of positive fungal cultures compared with the control. CONCLUSIONS: Plain socks and ZnO-NP socks significantly inhibited fungal growth relative to the control. The wearing of either plain socks or ZnO-NP socks can prevent fungal foot infection because these socks act as a barrier to the insoles of shoes. 2023-06-18T17:53:33Z 2023-06-18T17:53:33Z 2022-03-16 Article Journal of the American Podiatric Medical Association Vol.112 No.1 (2022) 10.7547/20-134 19308264 36459108 2-s2.0-85143379555 https://repository.li.mahidol.ac.th/handle/123456789/86027 SCOPUS
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Prasong W.
In Vitro Antifungal Activity of Plain Socks and Zinc Oxide Nanoparticle-Coated Socks
description BACKGROUND: Fungal foot infection is a common superficial fungal infection and is recognized as an important public health problem. Related to the wearing of occlusive footwear, foot infection is usually caused by dermatophytes and nondermatophyte molds. Previous in vitro studies have demonstrated that zinc oxide nanoparticles (ZnO-NPs) have antimicrobial activity against fungi. This study, therefore, evaluated the ability of socks coated with ZnO-NPs to inhibit fungal growth in an in vitro model mimicking real-life situations. METHODS: Scale from patients with fungal foot infections was equally divided into three groups: control, plain socks, and ZnO-NP socks. The specimens in the control group were routinely fungal cultured, whereas in the plain sock and ZnO-NP sock groups, scale was incubated with plain socks and ZnO-NP socks, respectively, for 24 hours. After incubation, each piece of sock was cultured. The fungal culture results of the three groups were progressively evaluated for 4 weeks. RESULTS: From 31 specimens, the positive fungal culture results of the control, plain sock, and ZnO-NP sock groups were 100%, 64.5%, and 54.8%, respectively. Specimens incubated with plain socks (P = .001) or with ZnO-NP socks (P < .001) had a significant reduction in the number of positive fungal cultures compared with the control. CONCLUSIONS: Plain socks and ZnO-NP socks significantly inhibited fungal growth relative to the control. The wearing of either plain socks or ZnO-NP socks can prevent fungal foot infection because these socks act as a barrier to the insoles of shoes.
author2 Mahidol University
author_facet Mahidol University
Prasong W.
format Article
author Prasong W.
author_sort Prasong W.
title In Vitro Antifungal Activity of Plain Socks and Zinc Oxide Nanoparticle-Coated Socks
title_short In Vitro Antifungal Activity of Plain Socks and Zinc Oxide Nanoparticle-Coated Socks
title_full In Vitro Antifungal Activity of Plain Socks and Zinc Oxide Nanoparticle-Coated Socks
title_fullStr In Vitro Antifungal Activity of Plain Socks and Zinc Oxide Nanoparticle-Coated Socks
title_full_unstemmed In Vitro Antifungal Activity of Plain Socks and Zinc Oxide Nanoparticle-Coated Socks
title_sort in vitro antifungal activity of plain socks and zinc oxide nanoparticle-coated socks
publishDate 2023
url https://repository.li.mahidol.ac.th/handle/123456789/86027
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